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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
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(2003) p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell, 3 (4). pp. 387-402. doi:10.1016/S1535-6108(03)00079-5 An open access version can be found in:
Official URL: http://dx.doi.org/10.1016/S1535-6108(03)00079-5
Abstract
Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers. Clinical response following cisplatin-based chemo-radiotherapy for advanced head and neck cancer is influenced by this polymorphism, cancers expressing 72R mutants having lower response rates than those expressing 72P mutants. Polymorphism in p53 may influence individual responsiveness to cancer therapy.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit | ||||||
| Journal or Publication Title: | Cancer Cell | ||||||
| Publisher: | Cell Press | ||||||
| ISSN: | 1535-6108 | ||||||
| Official Date: | 21 April 2003 | ||||||
| Dates: |
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| Volume: | 3 | ||||||
| Number: | 4 | ||||||
| Page Range: | pp. 387-402 | ||||||
| DOI: | 10.1016/S1535-6108(03)00079-5 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Open Access Version: |
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