The Library
Review of second-line chemotherapy for advanced gastric adenocarcinoma
Tools
Wilson, D., Hiller, Louise and Geh, J. I. (2005) Review of second-line chemotherapy for advanced gastric adenocarcinoma. Clinical Oncology, 17 (2). pp. 81-90. doi:10.1016/j.clon.2004.10.006
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.clon.2004.10.006
Abstract
Palliative chemotherapy has been shown to improve survival compared with best supportive care alone in patients with unresectable or recurrent gastric cancer. However, patients receiving chemotherapy eventually develop progressive disease. At this stage, no standard second-line chemotherapy can be offered. No randomised-controlled trial data suggest a benefit of second-line chemotherapy compared with supportive care alone. We review the published data concerning the use of second-line chemotherapy in gastric adenocarcinoma. Response rates to second-line therapy in phase II trials are similar to those seen for other cancers that are more commonly retreated. In addition, data suggest that patients who respond to second-line therapy consistently survive longer compared with non-responders, and, perhaps more importantly, symptomatic benefit may be obtained from second-line therapy.
Item Type: | Journal Item | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | Clinical Oncology | ||||
Publisher: | Elsevier Science London | ||||
ISSN: | 0936-6555 | ||||
Official Date: | 2 April 2005 | ||||
Dates: |
|
||||
Volume: | 17 | ||||
Number: | 2 | ||||
Page Range: | pp. 81-90 | ||||
DOI: | 10.1016/j.clon.2004.10.006 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |