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The use of an anabolic steroid (nandrolone decanoate) to improve nutritional status after esophageal resection for carcinoma
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Darnton, S. J., Zgainski, B., Grenier, I., Allister, K., Hiller, Louise, McManus, K. G. and Steyn, R. S. (1999) The use of an anabolic steroid (nandrolone decanoate) to improve nutritional status after esophageal resection for carcinoma. Diseases of the Esophagus, 12 (4). pp. 283-288. doi:10.1046/j.1442-2050.1999.00074.x ISSN 1120-8694.
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Official URL: http://dx.doi.org/10.1046/j.1442-2050.1999.00074.x
Abstract
Anabolic steroids increase appetite and muscle mass. This randomized, double-blind trial investigates any nutritional benefits of anabolic steroid in patients after surgery for esophageal cancer. Forty patients were recruited: 19 patients had five injections of 50 mg nandrolone decanoate and 21 patients received placebo over 3 months, starting 1 month after surgery. Measurements of body weight, mid-arm muscle circumference (MAMC) and appetite were taken over a 6-month period. Nutrition was optimized by dietary advice and by esophageal dilatation if required. Percent ideal weight, percent ideal MAMC and appetite score did not show significant differences between steroid and placebo groups, but there was a trend to an increase over 6 months for percent ideal MAMC in the test group. With this protocol, we have experienced minimal side-effects. However, we have not demonstrated any therapeutic benefit with low-dose steroid. An increased dose schedule over a longer period might produce a significant response.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Diseases of the Esophagus | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 1120-8694 | ||||
Official Date: | 1 December 1999 | ||||
Dates: |
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Volume: | 12 | ||||
Number: | 4 | ||||
Page Range: | pp. 283-288 | ||||
DOI: | 10.1046/j.1442-2050.1999.00074.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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