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A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders
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Nicholl, D. J., Bennett, P., Hiller, Louise, Bonifati, V., Vanacore, N., Fabbrini, G., Marconi, R., Colosimo, C., Lamberti, P., Stocchi, F., Bonuccelli, U., Vieregge, P., Ramsden, D. B., Meco, G. and Williams, A. C. (1999) A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. Neurology, 53 (7). pp. 1415-1421. doi:10.1212/WNL.53.7.1415
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Official URL: https://doi.org/10.1212/WNL.53.7.1415
Abstract
Objective: To determine whether reported genetic association of polymorphisms in the CYP2D6, CYP1A1, N-acetyltransferase 2 (NAT2), DAT1, and glutathione s-transferase M1 (GSTM1) genes with PD were evident in a population of 176 unrelated patients with sporadic PD and to extend these findings to other disease groups (familial PD [n = 30], ALS [n = 50], multiple system atrophy [n = 38], progressive supranuclear palsy [n = 35], and AD [n = 23]).
Methods: A combination of allele-specific PCR and analysis of restriction fragment length polymorphisms were performed.
Results: We genotyped 1,131 individuals. After matching each patient with a control subject by age, sex, ethnicity, and geographic origin, there was no association of any allele/genotype with any of the six disease groups. There was an increased frequency of NAT2 slow acetylators in the ALS group compared with controls (70% versus 50%; OR 2.33 [95% CI, 1.03 to 5.30]), but this was not significant after adjusting for multiple testing.
Conclusions: This is one of the most extensive candidate gene studies performed in PD and the first time that some of these loci have been studied in multiple system atrophy and progressive supranuclear palsy. In contrast with previous studies, we found no role for these polymorphisms in the etiology of PD, ALS, multiple system atrophy, progressive supranuclear palsy, or AD.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Neurology | ||||||
| Publisher: | Wolters Kluwer Health | ||||||
| ISSN: | 0028-3878 | ||||||
| Official Date: | 22 October 1999 | ||||||
| Dates: |
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| Volume: | 53 | ||||||
| Number: | 7 | ||||||
| Page Range: | pp. 1415-1421 | ||||||
| DOI: | 10.1212/WNL.53.7.1415 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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