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Randomised controlled double blind study of role of recombinant erythropoietin in the prevention of chronic lung disease
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Griffiths, G., Lall, Ranjit, Chatfield, S., Short, A., Mackay, P., Williamson, P., Brown, J. and Levene, M. I (1997) Randomised controlled double blind study of role of recombinant erythropoietin in the prevention of chronic lung disease. Archives of Disease in Childhood - Fetal and Neonatal Edition, 76 (3). F190-F192. doi:10.1136/fn.76.3.F190 ISSN 1359-2998.
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Official URL: http://dx.doi.org/10.1136/fn.76.3.F190
Abstract
Aim-To evaluate the role of recombinant human erythropoietin (R-HuEpo) in reducing iron infusion, which may exacerbate free radical damage, leading to chronic lung disease.
Methods-A multicentre, randomised, placebo controlled, double blind study was carried out in four neonatal intensive care units in Yorkshire. Infants were randomly allocated and received either R-HuEpo (480 U/kg/wk) or placebo by twice weekly subcutaneous injection. The primary outcome measure was the number of days on respiratory support and a secondary outcome the number of blood transfusions required.
Results-Forty two very low birthweight (VLBW) infants were randomly allocated. There was little difference in the need for respiratory support one month after randomisation, but subsequently there was a trend towards a reduction in the proportion requiring respiratory support in the R-HuEpo group (difference at three months -0.50, 95% confidence interval -1.00, 0.17). During stay in hospital, the median number of blood transfusions was lower for infants in the R-HuEpo group (difference in medians -2, 95% CI -4, 0). The study was stopped early because of failure to recruit babies at the expected rate.
Conclusions-R-HuEpo seems to reduce the number of days in oxygen for ill VLBW infants. These data could be used to construct a larger multicentre study to evaluate this effect further.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Archives of Disease in Childhood - Fetal and Neonatal Edition | ||||||
| Publisher: | British Medical Journal Publishing Group | ||||||
| ISSN: | 1359-2998 | ||||||
| Official Date: | May 1997 | ||||||
| Dates: |
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| Volume: | 76 | ||||||
| Number: | 3 | ||||||
| Page Range: | F190-F192 | ||||||
| DOI: | 10.1136/fn.76.3.F190 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Open Access Version: |
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