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Randomised controlled double blind study of role of recombinant erythropoietin in the prevention of chronic lung disease

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Griffiths, G., Lall, Ranjit, Chatfield, S., Short, A., Mackay, P., Williamson, P., Brown, J. and Levene, M. I (1997) Randomised controlled double blind study of role of recombinant erythropoietin in the prevention of chronic lung disease. Archives of Disease in Childhood - Fetal and Neonatal Edition, 76 (3). F190-F192. doi:10.1136/fn.76.3.F190 ISSN 1359-2998.

An open access version can be found in:
  • https://fn.bmj.com/content/fetalneonatal...
Official URL: http://dx.doi.org/10.1136/fn.76.3.F190

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Abstract

Aim-To evaluate the role of recombinant human erythropoietin (R-HuEpo) in reducing iron infusion, which may exacerbate free radical damage, leading to chronic lung disease.

Methods-A multicentre, randomised, placebo controlled, double blind study was carried out in four neonatal intensive care units in Yorkshire. Infants were randomly allocated and received either R-HuEpo (480 U/kg/wk) or placebo by twice weekly subcutaneous injection. The primary outcome measure was the number of days on respiratory support and a secondary outcome the number of blood transfusions required.

Results-Forty two very low birthweight (VLBW) infants were randomly allocated. There was little difference in the need for respiratory support one month after randomisation, but subsequently there was a trend towards a reduction in the proportion requiring respiratory support in the R-HuEpo group (difference at three months -0.50, 95% confidence interval -1.00, 0.17). During stay in hospital, the median number of blood transfusions was lower for infants in the R-HuEpo group (difference in medians -2, 95% CI -4, 0). The study was stopped early because of failure to recruit babies at the expected rate.

Conclusions-R-HuEpo seems to reduce the number of days in oxygen for ill VLBW infants. These data could be used to construct a larger multicentre study to evaluate this effect further.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Archives of Disease in Childhood - Fetal and Neonatal Edition
Publisher: British Medical Journal Publishing Group
ISSN: 1359-2998
Official Date: May 1997
Dates:
DateEvent
May 1997Published
2 January 1997Accepted
Volume: 76
Number: 3
Page Range: F190-F192
DOI: 10.1136/fn.76.3.F190
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Open Access Version:
  • https://fn.bmj.com/content/fetalneonatal...

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