Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment : the prevention of shoulder problems trial (UK PROSPER)

Tools
- Tools
+ Tools

PROSPER Study Group (Including: Richmond, Helen, Lait, Clare, Srikesavan, Cynthia, Williamson, Esther, Moser, Jane, Newman, Meredith, Betteley, Lauren, Fordham, Beth, Rees, Sophie, Lamb, S. E. (Sallie E.) and Bruce, J. (Julie)). (2018) Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment : the prevention of shoulder problems trial (UK PROSPER). BMC Health Services Research, 18 (1). 463. doi:10.1186/s12913-018-3280-x

[img] PDF
WRAP-development-exercise-intervention-prevention-musculoskeletal-shoulder-Bruce-2018 - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1752Kb)
Official URL: http://dx.doi.org/10.1186/s12913-018-3280-x

Request Changes to record.

Abstract

Background

Musculoskeletal shoulder problems are common after breast cancer treatment. There is some evidence to suggest that early postoperative exercise is safe and may improve shoulder function. We describe the development and delivery of a complex intervention for evaluation within a randomised controlled trial (RCT), designed to target prevention of musculoskeletal shoulder problems after breast cancer surgery (The Prevention of Shoulder Problems Trial; PROSPER).

Methods

A pragmatic, multicentre RCT to compare the clinical and cost-effectiveness of best practice usual care versus a physiotherapy-led exercise and behavioural support intervention in women at high risk of shoulder problems after breast cancer treatment. PROSPER will recruit 350 women from approximately 15 UK centres, with follow-up at 6 and 12 months. The primary outcome is shoulder function at 12 months; secondary outcomes include postoperative pain, health related quality of life, adverse events and healthcare resource use. A multi-phased approach was used to develop the PROSPER intervention which was underpinned by existing evidence and modified for implementation after input from clinical experts and women with breast cancer. The intervention was tested and refined further after qualitative interviews with patients newly diagnosed with breast cancer; a pilot RCT was then conducted at three UK clinical centres.

Discussion

The PROSPER intervention incorporates three main components: shoulder-specific exercises targeting range of movement and strength; general physical activity; and behavioural strategies to encourage adherence and support exercise behaviour. The final PROSPER intervention is fully manualised with clear, documented pathways for clinical assessment, exercise prescription, use of behavioural strategies, and with guidance for treatment of postoperative complications. This paper adheres to TIDieR and CERT recommendations for the transparent, comprehensive and explicit reporting of complex interventions.

Trial registration: International Standard Randomised Controlled Trial Number: ISRCTN 35358984.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RD Surgery
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Breast -- Cancer -- Surgery -- Complications, Shoulder -- Diseases
Journal or Publication Title: BMC Health Services Research
Publisher: Biomed Central Ltd
ISSN: 1472-6963
Official Date: 18 June 2018
Dates:
DateEvent
18 June 2018Published
5 June 2018Accepted
Date of first compliant deposit: 20 July 2018
Volume: 18
Number: 1
Article Number: 463
DOI: 10.1186/s12913-018-3280-x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: The Authors
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
13/84/10Health Technology Assessment programmehttp://dx.doi.org/10.13039/501100000664

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us