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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
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Social Science Genetic Association Consortium (Including:
). (2018) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 . pp. 1112-1121. doi:10.1038/s41588-018-0147-3
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WRAP-gene-discovery-polygenic-prediction-genome-educational-million-Cappuccio-2018.pdf - Accepted Version - Requires a PDF viewer. Download (983Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41588-018-0147-3
Abstract
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million
individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuronto-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||||||||||||||||||||||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Educational attainment -- Genetic aspects, Single nucleotide polymorphisms, Medical genetics, Phenotype | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Nature Genetics | ||||||||||||||||||||||||||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||||||||||||||||||||||||||
| ISSN: | 1061-4036 | ||||||||||||||||||||||||||||||||||||
| Official Date: | 23 July 2018 | ||||||||||||||||||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 10 August 2018 | ||||||||||||||||||||||||||||||||||||
| Volume: | 50 | ||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 1112-1121 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1038/s41588-018-0147-3 | ||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||||||||
| Copyright Holders: | The Author(s) | ||||||||||||||||||||||||||||||||||||
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