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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

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Social Science Genetic Association Consortium (Including:

Lee, James J., Wedow, Robbee, Okbay, Aysu, Kong, Edward, Maghzian, Omeed, Zacher, Meghan, Nguyen-Viet, Tuan Anh, Bowers, Peter, Sidorenko, Julia, Karlsson Linnér, Richard et al.
). (2018) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 . pp. 1112-1121. doi:10.1038/s41588-018-0147-3

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Official URL: http://dx.doi.org/10.1038/s41588-018-0147-3

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Abstract

Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million
individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuronto-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Educational attainment -- Genetic aspects, Single nucleotide polymorphisms, Medical genetics, Phenotype
Journal or Publication Title: Nature Genetics
Publisher: Nature Publishing Group
ISSN: 1061-4036
Official Date: 23 July 2018
Dates:
DateEvent
23 July 2018Published
30 April 2018Accepted
Date of first compliant deposit: 10 August 2018
Volume: 50
Page Range: pp. 1112-1121
DOI: 10.1038/s41588-018-0147-3
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Copyright Holders: The Author(s)
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
E9/11Ragnar Söderbergs stiftelsehttp://dx.doi.org/10.13039/100007459
E24/15Ragnar Söderbergs stiftelsehttp://dx.doi.org/10.13039/100007459
421-2013-1061Vetenskapsrådethttp://dx.doi.org/10.13039/501100004359
UNSPECIFIEDJan Wallanders och Tom Hedelius Stiftelse samt Tore Browaldhs Stiftelsehttp://dx.doi.org/10.13039/100007439
647648 EdGeH2020 Excellent Sciencehttp://dx.doi.org/10.13039/100010662
Pershing Square Fund of the Foundations of Human BehaviorPershing Square Foundationhttp://dx.doi.org/10.13039/100010304
P01-AG005842National Institute on Aginghttp://dx.doi.org/10.13039/100000049
P01-AG005842-20S2National Institute on Aginghttp://dx.doi.org/10.13039/100000049
P30-AG012810National Institute on Aginghttp://dx.doi.org/10.13039/100000049
T32-AG000186-23National Institute on Aginghttp://dx.doi.org/10.13039/100000049
R01-AG042568National Institute on Aginghttp://dx.doi.org/10.13039/100000049
Contributors:
ContributionNameContributor ID
ResearcherCappuccio, Francesco13620

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