1st class ticket to class I: Protein toxins as pathfinders for antigen presentation
UNSPECIFIED (2002) 1st class ticket to class I: Protein toxins as pathfinders for antigen presentation. TRAFFIC, 3 (10). pp. 697-704. ISSN 1398-9219Full text not available from this repository.
A number of bacterial toxins have evolved diverse strategies for crossing membrane barriers in order to reach their substrates in the mammalian cytosol. Recent studies show that this property can be exploited for the delivery of fused antigens into the major histocompatibility complex class I-restricted presentation pathway, with the goal of eliciting a specific immune response. Here we discuss the peculiarities of the trafficking pathways of a variety of toxins, and how these may allow the toxins to be used as delivery vehicles for therapeutic and diagnostic purposes.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||TRAFFIC|
|Official Date:||October 2002|
|Number of Pages:||8|
|Page Range:||pp. 697-704|
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