UNSPECIFIED (2002) The use of microarray technology for the analysis of Streptococcus pneumoniae. In: 1st Symposium of the Wellcome Trust Funded Mult-Collaborative Microbial Pathogen Microrray Facility, CAMBRIDGE, ENGLAND, MAY 23-24, 2002. Published in: COMPARATIVE AND FUNCTIONAL GENOMICS, 3 (4). pp. 366-368.

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Abstract

Streptococcus pneumoniae is an important human pathogen associated with pneumonia, septicaemia, meningitis and otitis media. It is estimated to result in over 3 million child deaths worldwide every year and an even greater number of deaths among the elderly. Prior to the complete sequencing of the genomes of S. pneumoniae TIGR4 (serotype 4) and S. pneumoniae R6 (serotype 2), we designed a custom miniarray consisting of 497 pneumococcal genes. The overall objectives of our microarray investigations were, first, to assess the genetic diversity between different S. pneumoniae serotypes, clinical isolates and also different Streptococcus species; second, we aimed to use microarray technology to examine the mechanisms by which environmental factors influence pneumococcal gene expression, and ultimately to further the understanding of how these changes in gene expression are achieved and how they may after the virulence of the organism. Copyright (C) John Wiley Sons, Ltd.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology Q Science > QH Natural history > QH426 Genetics
Journal or Publication Title:	COMPARATIVE AND FUNCTIONAL GENOMICS
Publisher:	JOHN WILEY & SONS LTD
ISSN:	1531-6912
Date:	August 2002
Volume:	3
Number:	4
Number of Pages:	3
Page Range:	pp. 366-368
Identification Number:	10.1002/cfg.190
Publication Status:	Published
Title of Event:	1st Symposium of the Wellcome Trust Funded Mult-Collaborative Microbial Pathogen Microrray Facility
Location of Event:	CAMBRIDGE, ENGLAND
Date(s) of Event:	MAY 23-24, 2002
URI:	http://wrap.warwick.ac.uk/id/eprint/10589

Data sourced from Thomson Reuters' Web of Knowledge

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