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Bench-to-bedside review : β2-agonists and the acute respiratory distress syndrome
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Perkins, Gavin D., McAuley, Daniel F., Richter, Alex, Thickett, David R. and Gao, Fang (2003) Bench-to-bedside review : β2-agonists and the acute respiratory distress syndrome. Critical Care, 8 (1). p. 25. doi:10.1186/cc2417
An open access version can be found in:
Official URL: http://dx.doi.org/10.1186/cc2417
Abstract
The acute respiratory distress syndrome (ARDS) is a devastating constellation of clinical, radiological and pathological signs characterized by failure of gas exchange and refractory hypoxia. Despite nearly 30 years of research, no specific pharmacological therapy has yet proven to be efficacious in manipulating the pathophysiological processes that underlie this condition. Several in vitro and in vivo animal or human studies suggest a potential role for β2-agonists in the treatment of ARDS. These agents have been shown to reduce pulmonary neutrophil sequestration and activation, accelerate alveolar fluid clearance, enhance surfactant secretion, and modulate the inflammatory and coagulation cascades. They are also used widely in clinical practice and are well tolerated in critically ill patients. The present review examines the evidence supporting a role for β2-agonists as a specific pharmacological intervention in patients with ARDS.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Critical Care | ||||
| Publisher: | Springer Nature | ||||
| ISSN: | 1364-8535 | ||||
| Official Date: | 23 December 2003 | ||||
| Dates: |
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| Volume: | 8 | ||||
| Number: | 1 | ||||
| Page Range: | p. 25 | ||||
| DOI: | 10.1186/cc2417 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Open Access Version: |
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