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Effects of high dose vitamin D supplementation in patients undergoing oesophagectomy
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Dancer, R., Parekh, D., Martineau, A., Perkins, Gavin D. and Thickett, D. (2014) Effects of high dose vitamin D supplementation in patients undergoing oesophagectomy. European Respiratory Journal, 42 . 1817.
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Official URL: http://erj.ersjournals.com/content/42/Suppl_57/181...
Abstract
Acute Lung Injury (ALI) occurs in around 25% of patients post oesophagectomy. We have previously shown that levels of 25-OH vitamin D (25D) are low in these patients and that the most deficient patients are more likely to develop post-op ALI.
We gave 13 patients a one-off high dose vitamin D supplement 3-14 days prior to oesophagectomy. Plasma 25D levels were measured pre-supplement, preop and day1 and 3 post-op. Preop, post-op and day1 PICCO measurements of extravascular lung water index (EVLWi) and pulmonary vascular permeability index (PVPI) were taken in 7 of the patients. Results were compared with a cohort of patients (n=50) who were all vitamin D deficient (mean preop vitamin D level=26.1).
The majority of supplemented patients achieved sufficient plasma 25D levels (>50nmol/L) preoperatively (mean=69.3) Mean plasma 25D levels fell significantly perioperatively to 49.5 on day1 post-op and 43.7 on day3 post-op (p<0.001). Preop 25D levels were significantly different between the supplemented and deficient groups (p<0.001). There were significant differences between the two groups in perioperative change in EVLWi and PVPI.
Item Type: | Journal Item | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | European Respiratory Journal | ||||
Publisher: | European Respiratory Society | ||||
ISSN: | 0903-1936 | ||||
Official Date: | 25 July 2014 | ||||
Dates: |
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Volume: | 42 | ||||
Article Number: | 1817 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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