Parekh, D., Dancer, R., Park, D., Perkins, Gavin D. and Thickett, D. (2013) Salmeterol prevents pneumonia and reduces biomarkers of inflammation/epithelial damage but not acute lung injury following oesophagectomy-the results of BALTI-prevention trial. European Respiratory Journal, 42 . 1818.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

To determine if perioperative treatment with inhaled β-agonists effects the development of ALI in adult patients undergoing elective oesophagectomy we conducted a multi-centre randomized placebo controlled trial in 12 centres across the UK.Patients received inhaled salmeterol (100mcg bd, n=170) or placebo(n=171) for 3 days.53 consecutively recruited patients were enrolled in a translational sub-study.

Effects of salmeterol on rates of ALI,adverse events and pneumonia are summarized in table 1.Salmeterol had no effect on the incidence of ALI.Post-operative pneumonia was reduced in the salmeterol group (number needed to treat to prevent one infection=17).

Salmeterol treatment significantly reduced the change in PICCO measured pulmonary vascular permeability index (p=0.008).Circulating inflammatory cytokines IL1-β (p<0.05) and TNF-α (p<0.05) were reduced post-operatively.Circulating markers of endothelial (sICAM-1, P=0.01) and epithelial damage (sRAGE, P=0.05) were reduced in the salmeterol group at post-operative day1.

Salmeterol had no effect on the incidence of ALI following oesophagectomy but reduced markers of inflammation and epithelial damage.Salmeterol treatment significantly reduced the number of patients developing hospital acquired pneumonia. Further studies are required to see if salmeterol can prevent other hospital acquired pneumonias.

Item Type:	Journal Item
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	European Respiratory Journal
Publisher:	European Respiratory Society
ISSN:	0903-1936
Official Date:	September 2013
Dates:	Date Event September 2013 Published
Volume:	42
Article Number:	1818
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item