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Systematic review and meta-analysis : does colonic mural thickening on CT correlate with endoscopic findings at colonoscopy?
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Chandrapalan, Subashini, Tahir, Faraz, Kimani, Peter K., Sinha, Rakesh and Arasaradnam, Ramesh P. (2018) Systematic review and meta-analysis : does colonic mural thickening on CT correlate with endoscopic findings at colonoscopy? Frontline Gastroenterology . doi:10.1136/flgastro-2018-100966 (In Press)
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WRAP-systematic-review-meta-analysis-colonic-mural-thickening-Kimani-2018 .pdf - Accepted Version - Requires a PDF viewer. Download (723Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/flgastro-2018-100966
Abstract
Background: Colonic mural thickening (MT) is often reported on standard Computed Tomography (CT) examinations of the abdomen and pelvis. It often presents a dilemma for the clinician on whether any further evaluation is needed, especially in the absence of any set guidelines. Objective: To evaluate the significance of colonic mural thickening and to assess its correlation with colonoscopy. Methods: The search strategy was initially developed in MEDLINE and adapted for use in EMBASE, MEDLINE, NHS Evidence and TRIP. Studies were included if they’d reported colonic MT and subsequent colonoscopy in adults. Results: A total of 9 cohort studies examining 1252 patients were selected having undergone both CT and colonoscopy. Of the 1252 patients with MT, 950 had an abnormal colonoscopy. In the presence of MT, the pooled positive predictive value (PPV) of having any abnormal findings at colonoscopy was 0.73 (95% CI = 0.60 to 0.84). The pooled PPV for colorectal cancer, in the presence of MT reporting suspicion of cancer, was 0.63 (95% CI = 0.49 to 0.75) and MT suggestive of inflammation confirmed at colonoscopy was 0.97.
Conclusion: The probability of having an abnormal colonoscopy in the presence of MT identified on CT is high, especially for inflammation. Asymptomatic cancers may also be detected, hence further endoscopic confirmation is reasonable when a finding of MT is demonstrated on CT examinations. Small sample sizes of the available studies and lack of data on the description of MT detected are the main limiting factors in this review.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QL Zoology Q Science > QM Human anatomy R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Colon (Anatomy), Colon (Anatomy) -- Examination, Colonoscopy , Colon (Anatomy) -- Tomography | ||||||
| Journal or Publication Title: | Frontline Gastroenterology | ||||||
| Publisher: | BMJ Group | ||||||
| ISSN: | 2041-4137 | ||||||
| Official Date: | 26 June 2018 | ||||||
| Dates: |
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| Date of first compliant deposit: | 27 July 2018 | ||||||
| DOI: | 10.1136/flgastro-2018-100966 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | In Press | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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