Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Systematic review and meta-analysis : does colonic mural thickening on CT correlate with endoscopic findings at colonoscopy?

Tools
- Tools
+ Tools

Chandrapalan, Subashini, Tahir, Faraz, Kimani, Peter K., Sinha, Rakesh and Arasaradnam, Ramesh P. (2018) Systematic review and meta-analysis : does colonic mural thickening on CT correlate with endoscopic findings at colonoscopy? Frontline Gastroenterology, 9 (4). pp. 278-284. doi:10.1136/flgastro-2018-100966

[img]
Preview
PDF
WRAP-systematic-review-meta-analysis-colonic-mural-thickening-Kimani-2018 .pdf - Accepted Version - Requires a PDF viewer.

Download (723Kb) | Preview
Official URL: http://dx.doi.org/10.1136/flgastro-2018-100966

Request Changes to record.

Abstract

Background: Colonic mural thickening (MT) is often reported on standard Computed Tomography (CT) examinations of the abdomen and pelvis. It often presents a dilemma for the clinician on whether any further evaluation is needed, especially in the absence of any set guidelines. Objective: To evaluate the significance of colonic mural thickening and to assess its correlation with colonoscopy. Methods: The search strategy was initially developed in MEDLINE and adapted for use in EMBASE, MEDLINE, NHS Evidence and TRIP. Studies were included if they’d reported colonic MT and subsequent colonoscopy in adults. Results: A total of 9 cohort studies examining 1252 patients were selected having undergone both CT and colonoscopy. Of the 1252 patients with MT, 950 had an abnormal colonoscopy. In the presence of MT, the pooled positive predictive value (PPV) of having any abnormal findings at colonoscopy was 0.73 (95% CI = 0.60 to 0.84). The pooled PPV for colorectal cancer, in the presence of MT reporting suspicion of cancer, was 0.63 (95% CI = 0.49 to 0.75) and MT suggestive of inflammation confirmed at colonoscopy was 0.97.

Conclusion: The probability of having an abnormal colonoscopy in the presence of MT identified on CT is high, especially for inflammation. Asymptomatic cancers may also be detected, hence further endoscopic confirmation is reasonable when a finding of MT is demonstrated on CT examinations. Small sample sizes of the available studies and lack of data on the description of MT detected are the main limiting factors in this review.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Q Science > QM Human anatomy
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Colon (Anatomy), Colon (Anatomy) -- Examination, Colonoscopy , Colon (Anatomy) -- Tomography
Journal or Publication Title: Frontline Gastroenterology
Publisher: BMJ Group
ISSN: 2041-4137
Official Date: 7 September 2018
Dates:
DateEvent
7 September 2018Published
26 June 2018Available
27 May 2018Accepted
Volume: 9
Number: 4
Page Range: pp. 278-284
DOI: 10.1136/flgastro-2018-100966
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us