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Heparin-mimicking sulfonated polymer nanoparticles via RAFT polymerization-induced self-assembly
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Gurnani, Pratik, Bray, Caroline, Richardson, Robert A. E., Peltier, Raoul and Perrier, Sébastien (2019) Heparin-mimicking sulfonated polymer nanoparticles via RAFT polymerization-induced self-assembly. Macromolecular Rapid Communications, 40 (2). 1800314. doi:10.1002/marc.201800314 ISSN 1022-1336.
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WRAP-heparin-mimicking-sulfonated-polymer-nanoparticles-Perrier-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1605Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/marc.201800314
Abstract
Heparin plays a significant role in wound healing and tissue regeneration applications, through stabilization of fibroblast growth factors (FGF). Risks associated with batch‐to‐batch variability and contamination from its biological sources have led to the development of synthetic, highly sulfonated polymers as promising heparin mimics. In this work, a systematic study of an aqueous polymerization‐induced self‐assembly (PISA) of styrene from poly(2‐acrylamido‐2‐methylpropane sodium sulfonate) (P(AMPS)) macro reversible addition–fragmentation chain transfer (macro‐RAFT) agents produced a variety of spherical heparin‐mimicking nanoparticles, which were further characterized with light scattering and electron microscopy techniques. None of the nanoparticles tested showed toxicity against mammalian cells; however, significant hemolytic activity was observed. Nonetheless, the heparin‐mimicking nanoparticles outperformed both heparin and linear P(AMPS) in cellular proliferation assays, suggesting increased bFGF stabilization efficiencies, possibly due to the high density of sulfonated moieties at the particle surface.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Addition polymerization, Heparin, Nanoparticles, Fragmentation reactions | |||||||||||||||
| Journal or Publication Title: | Macromolecular Rapid Communications | |||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | |||||||||||||||
| ISSN: | 1022-1336 | |||||||||||||||
| Official Date: | January 2019 | |||||||||||||||
| Dates: |
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| Volume: | 40 | |||||||||||||||
| Number: | 2 | |||||||||||||||
| Article Number: | 1800314 | |||||||||||||||
| DOI: | 10.1002/marc.201800314 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Reuse Statement (publisher, data, author rights): | This is the pre-peer reviewed version of the following article: P. Gurnani, C. P. Bray, R. A. E. Richardson, R. Peltier, S. Perrier, Macromol. Rapid Commun. 2018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Date of first compliant deposit: | 8 August 2018 | |||||||||||||||
| Date of first compliant Open Access: | 12 July 2020 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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