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Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates
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Mansfield, Edward D. H., Hartlieb, Matthias, Catrouillet, Sylvain, Rho, Julia Y., Larnaudie, Sophie C., Rogers, Sarah E., Sanchis, Joaquin, Brendel, Johannes C. and Perrier, Sébastien (2018) Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates. Soft Matter, 14 (30). pp. 6320-6326. doi:10.1039/C8SM01133H
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WRAP-systematic-study-structural-parameters-affecting-self-assembly-Perrier-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1041Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C8SM01133H
Abstract
Self-assembling cyclic peptides (CP) consisting of amino acids with alternating D- and L-chirality form nanotubes by hydrogen bonding, hydrophobic interactions, and π–π stacking in solution. These highly dynamic materials are emerging as promising supramolecular systems for a wide range of biomedical applications. Herein, we discuss how varying the polymer conformation (linear vs. brush), as well as the number of polymer arms per peptide unimer affects the self-assembly of PEGylated cyclic peptides in different solvents, using small angle neutron scattering. Using the derived information, strong correlations were drawn between the size of the aggregates, solvent polarity, and its ability to compete for hydrogen bonding interactions between the peptide unimers. Using these data, it could be possible to engineer cyclic peptide nanotubes of a controlled length.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||||||||||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cyclic peptides, Nanotubes, Supramolecular chemistry | ||||||||||||||||||||||||
| Journal or Publication Title: | Soft Matter | ||||||||||||||||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||||||||||||||||
| ISSN: | 1744-683X | ||||||||||||||||||||||||
| Official Date: | 6 July 2018 | ||||||||||||||||||||||||
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| Volume: | 14 | ||||||||||||||||||||||||
| Number: | 30 | ||||||||||||||||||||||||
| Page Range: | pp. 6320-6326 | ||||||||||||||||||||||||
| DOI: | 10.1039/C8SM01133H | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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