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Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates

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Mansfield, Edward D. H., Hartlieb, Matthias, Catrouillet, Sylvain, Rho, Julia Y., Larnaudie, Sophie C., Rogers, Sarah E., Sanchis, Joaquin, Brendel, Johannes C. and Perrier, Sébastien (2018) Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates. Soft Matter, 14 (30). pp. 6320-6326. doi:10.1039/C8SM01133H ISSN 1744-683X.

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Official URL: http://dx.doi.org/10.1039/C8SM01133H

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Abstract

Self-assembling cyclic peptides (CP) consisting of amino acids with alternating D- and L-chirality form nanotubes by hydrogen bonding, hydrophobic interactions, and π–π stacking in solution. These highly dynamic materials are emerging as promising supramolecular systems for a wide range of biomedical applications. Herein, we discuss how varying the polymer conformation (linear vs. brush), as well as the number of polymer arms per peptide unimer affects the self-assembly of PEGylated cyclic peptides in different solvents, using small angle neutron scattering. Using the derived information, strong correlations were drawn between the size of the aggregates, solvent polarity, and its ability to compete for hydrogen bonding interactions between the peptide unimers. Using these data, it could be possible to engineer cyclic peptide nanotubes of a controlled length.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Cyclic peptides, Nanotubes, Supramolecular chemistry
Journal or Publication Title: Soft Matter
Publisher: Royal Society of Chemistry
ISSN: 1744-683X
Official Date: 6 July 2018
Dates:
DateEvent
6 July 2018Available
4 July 2018Accepted
Volume: 14
Number: 30
Page Range: pp. 6320-6326
DOI: 10.1039/C8SM01133H
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 8 August 2018
Date of first compliant Open Access: 6 July 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
WM130055[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
UNSPECIFIEDMonash-Warwick AllianceUNSPECIFIED
647106H2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
HA7725/1-1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BR4905/1-1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BR4905/2-1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
RB1510236[STFC] Science and Technology Facilities Councilhttp://dx.doi.org/10.13039/501100000271

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