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25-hydroxyvitamin D serum levels in patients with high risk resected melanoma treated in an adjuvant bevacizumab trial
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Lipplaa, Astrid, Fernandes, Ricardo, Marshall, Andrea, Lorigan, Paul, Dunn, Janet A., Myers, Kevin A, Barker, Emily, Newton-Bishop, Julia, Middleton, Mark R. and Corrie, Pippa G. (2018) 25-hydroxyvitamin D serum levels in patients with high risk resected melanoma treated in an adjuvant bevacizumab trial. British Journal of Cancer . doi:10.1038/s41416-018-0179-6 (In Press)
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WRAP-25-hydroxyvitamin-D-serum-patients-high-risk-Marshall-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (373Kb) | Preview |
Official URL: http://doi.org/10.1038/s41416-018-0179-6
Abstract
Background
Studies evaluating a relationship of vitamin D in patients with primary melanoma have consistently identi fi ed an inverse correlation with Breslow thickness, but an inconsistent impact on survival. Vitamin D in later stages of melanoma has been less studied.
Methods
Vitamin D was measured in serum from 341 patients with resected stage IIB – IIIC melanoma recruited to the AVAST-M adjuvant melanoma randomised trial, collected prior to randomisation, then at 3 and 12 months. Vitamin D levels were compared with patient demographics, known melanoma prognostic factors, disease-free interval (DFI) and overall survival (OS).
Results
A total of 73% patients had stage III melanoma, 32% were enroled (and therefore tested) >1 year after primary melanoma diagnosis. Median pre-randomisation vitamin D level was 56.5 (range 12.6 – 189.0 nmol/L). Vitamin D levels did not signi fi cantly vary over 12 months ( p = 0.24). Individual pre-randomisation vitamin D levels did not differ signi fi cantly for Breslow thickness, tumour ulceration, or disease stage. Neither did pre-randomisation vitamin D predict for DFI (HR = 0.98 per 10 nmol/L increase; 95% con fi dence interval (CI) 0.93 – 1.04, p = 0.59) or OS (HR = 0.96 per 10 nmol/L increase, 95% CI 0.90 – 1.03, p = 0.31). For stage II patients, DFI improved with higher pre-randomisation vitamin D levels for those on bevacizumab (HR = 0.74 per 10 nmol nmol/L increase; 95% CI 0.56 – 0.97), but not for the observation arm (HR = 1.07 per 10 nmol/L increase; 95% CI 0.85 – 1.34).
Conclusions
In this stage II/III melanoma cohort, vitamin D did not correlate with known prognostic markers, nor predict for DFI or OS, but there was some evidence of bene fi t for patients with stage II disease treated with bevacizumab
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | |||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Bevacizumab, Melanoma, Clinical trials | |||||||||
| Journal or Publication Title: | British Journal of Cancer | |||||||||
| Publisher: | Nature Publishing Group | |||||||||
| ISSN: | 0007-0920 | |||||||||
| Official Date: | 23 July 2018 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 9 August 2018 | |||||||||
| DOI: | 10.1038/s41416-018-0179-6 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | In Press | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| Copyright Holders: | The Author(s) | |||||||||
| RIOXX Funder/Project Grant: |
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