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Ionic liquids for preparation of biopolymer materials for drug/gene delivery : a review
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Chen, Jing, Xie, Fengwei, Chen, Ling and Li, Xiaoxi (2018) Ionic liquids for preparation of biopolymer materials for drug/gene delivery : a review. Green Chemistry, 20 . pp. 4169-4200. doi:10.1039/C8GC01120F
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WRAP-ionic-liquids-preparation-biopolymer-materials-drug-delivery-Xie-2018.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 7 August 2019. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (2129Kb) |
Official URL: http://dx.doi.org/10.1039/C8GC01120F
Abstract
Biopolymers are particularly suitable for drug applications due to their biocompatibility, biodegradability and low immunogenicity. There has been growing interest in using biopolymers to achieve the controlled release of therapeutics. However, the solubility and processability of biopolymers remain to be challenging due to their structural heterogeneity and dense networks of inter- and intramolecular interactions. Fortunately, ionic liquids (ILs), regarded as green solvents, have been increasingly appreciated for their unparalleled power for biopolymer processing. By dissolution of biopolymers in ILs, various materials including sponges, films, microparticles (MPs), nanoparticles (NPs), and aerogels can be generated as potential drug delivery carriers. Besides, ILs can be used as reaction mediums and/or catalysts for biopolymer chemical reactions, which shows enhanced reaction efficiency. In addition, because of their unique physicochemical (e.g., polarity, hydrophobicity, amphipathicity) and biological properties (e.g., antibacterial activity), ILs can assist or participate in the formation of drug delivery carriers. To cover all these aspects of research, this review provides an overview of the recent progress in using ILs for the engineering of next-generation drug/gene delivery carrier materials. The tunable properties of ILs as affected by their structure are highlighted. Also, the key principles, challenges and prospects in this area are presented.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | R Medicine > RS Pharmacy and materia medica T Technology > TP Chemical technology |
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| Divisions: | Other > Institute of Advanced Study | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Drugs -- Controlled release, Biopolymers, Biocompatibility | |||||||||||||||||||||
| Journal or Publication Title: | Green Chemistry | |||||||||||||||||||||
| Publisher: | Royal Society of Chemistry | |||||||||||||||||||||
| ISSN: | 1463-9262 | |||||||||||||||||||||
| Official Date: | 7 August 2018 | |||||||||||||||||||||
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| Date of first compliant deposit: | 9 August 2018 | |||||||||||||||||||||
| Volume: | 20 | |||||||||||||||||||||
| Page Range: | pp. 4169-4200 | |||||||||||||||||||||
| DOI: | 10.1039/C8GC01120F | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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