Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Ionic liquids for the preparation of biopolymer materials for drug/gene delivery : a review

Tools
- Tools
+ Tools

Chen, Jing, Xie, Fengwei, Chen, Ling and Li, Xiaoxi (2018) Ionic liquids for the preparation of biopolymer materials for drug/gene delivery : a review. Green Chemistry, 20 . pp. 4169-4200. doi:10.1039/C8GC01120F

[img]
Preview
PDF
WRAP-ionic-liquids-preparation-biopolymer-materials-drug-delivery-Xie-2018.pdf - Accepted Version - Requires a PDF viewer.

Download (2129Kb) | Preview
Official URL: http://dx.doi.org/10.1039/C8GC01120F

Request Changes to record.

Abstract

Biopolymers are particularly suitable for drug applications due to their biocompatibility, biodegradability and low immunogenicity. There has been growing interest in using biopolymers to achieve the controlled release of therapeutics. However, the solubility and processability of biopolymers remain to be challenging due to their structural heterogeneity and dense networks of inter- and intramolecular interactions. Fortunately, ionic liquids (ILs), regarded as green solvents, have been increasingly appreciated for their unparalleled power for biopolymer processing. By dissolution of biopolymers in ILs, various materials including sponges, films, microparticles (MPs), nanoparticles (NPs), and aerogels can be generated as potential drug delivery carriers. Besides, ILs can be used as reaction mediums and/or catalysts for biopolymer chemical reactions, which shows enhanced reaction efficiency. In addition, because of their unique physicochemical (e.g., polarity, hydrophobicity, amphipathicity) and biological properties (e.g., antibacterial activity), ILs can assist or participate in the formation of drug delivery carriers. To cover all these aspects of research, this review provides an overview of the recent progress in using ILs for the engineering of next-generation drug/gene delivery carrier materials. The tunable properties of ILs as affected by their structure are highlighted. Also, the key principles, challenges and prospects in this area are presented.

Item Type: Journal Article
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Divisions: Other > Institute of Advanced Study
Library of Congress Subject Headings (LCSH): Drugs -- Controlled release, Biopolymers, Biocompatibility
Journal or Publication Title: Green Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1463-9262
Official Date: 7 August 2018
Dates:
DateEvent
7 August 2018Available
7 August 2018Accepted
Volume: 20
Page Range: pp. 4169-4200
DOI: 10.1039/C8GC01120F
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
U1501214[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
201804020036Guangzhou Science and Technology Program key projectshttp://dx.doi.org/10.13039/501100004000
2014YT02S029[MSTPRC] Ministry of Science and Technology of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002855
2014B090904047Natural Science Foundation of Guangdong Provincehttp://dx.doi.org/10.13039/501100003453
UNSPECIFIEDH2020 Marie Skłodowska-Curie Actionshttp://dx.doi.org/10.13039/100010665
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us