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In vivo estimation of water diffusivity in occluded human skin using terahertz reflection spectroscopy
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Sun, Qiushuo, Stantchev, Rayko I., Wang, Jiarui, Parrott, Edward P. J., Cottenden, Alan, Chiu, Tor-Wo, Ahuja, Anil T. and Pickwell-MacPherson, Emma (2019) In vivo estimation of water diffusivity in occluded human skin using terahertz reflection spectroscopy. Journal of Biophotonics, 12 (2). e201800145. doi:10.1002/jbio.201800145 ISSN 1864-063X.
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WRAP-In-vivo-estimation-water-diffusivity-occluded-human-skin-Pickwell-MacPherson-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1340Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/jbio.201800145
Abstract
Water diffusion and the concentration profile within the skin significantly affect the surrounding chemical absorption and molecular synthesis. Occluding the skin causes water to accumulate in the top layer of the skin (the stratum corneum) and also affects the water diffusivity. Scar treatments such as silicone gel and silicone sheets make use of occlusion to increase skin hydration. However with existing techniques, it is not possible to quantitatively measure the diffusivity of the water during occlusion: current methods determine water diffusivity by measuring the water evaporated through the skin and thus require the skin to breathe. In this work we use the high sensitivity of terahertz light to water to study how the water content in the stratum corneum changes upon occlusion. From our measurements, we can solve the diffusion equations in the stratum corneum to deduce the water concentration profile in occluded skin and subsequently to determine the diffusivity. To our knowledge this is the first work showing how the diffusivity of human skin can be measured during occlusion and we envisage this paper as being used as a guide for non‐invasively determining the diffusivity of occluded human skin in vivo.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QM Human anatomy | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Skin -- Health aspects, Hydration, Terahertz spectroscopy | ||||||||||||||||||
| Journal or Publication Title: | Journal of Biophotonics | ||||||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||||||||||
| ISSN: | 1864-063X | ||||||||||||||||||
| Official Date: | February 2019 | ||||||||||||||||||
| Dates: |
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| Volume: | 12 | ||||||||||||||||||
| Number: | 2 | ||||||||||||||||||
| Article Number: | e201800145 | ||||||||||||||||||
| DOI: | 10.1002/jbio.201800145 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | This is the pre-peer reviewed version of the following article: Collier, G. J., Kim, M. , Chung, Y. and Wild, J. M. (2018), 3D phase contrast MRI in models of human airways: Validation of computational fluid dynamics simulations of steady inspiratory flow. J. Magn. Reson. Imaging. . doi:10.1002/jmri.26039, which has been published in final form at https://doi.org/10.1002/jmri.26039. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Date of first compliant deposit: | 10 August 2018 | ||||||||||||||||||
| Date of first compliant Open Access: | 10 July 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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