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RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles
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Gurnani, Pratik, Sanchez-Cano, Carlos, Abraham, Kristin, Xandri-Monje, Helena, Cook, Alexander B., Hartlieb, Matthias, Lévi, Francis A., Dallmann, Robert and Perrier, Sébastien (2019) RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles. Macromolecular Bioscience, 18 (10). 1800213. doi:10.1002/mabi.201800213 ISSN 1616-5187.
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WRAP-RAFT-emulsion-polymerization-generate-latex-Gurnani-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1417Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/mabi.201800213
Abstract
Current approaches to generate core–shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming these challenges. In this work, well‐defined PEGylated nanoparticles are synthesized using reversible addition fragmentation chain transfer emulsion polymerization to control particle size and surface composition and were further characterized with light scattering, electron microscopy, and size exclusion chromatography. Importantly, the nanoparticles are found to be tolerated both in vitro and in vivo, without the need for any purification after particle synthesis. Pharmacokinetic and biodistribution studies in mice, following intraperitoneal injection of the nanoparticles, reveal a long (>76 h) circulation time and accumulation in the liver.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Emulsion polymerization, Biomedical materials, Nanoparticles, Latex, Fragmentation reactions | ||||||||||||||||||
| Journal or Publication Title: | Macromolecular Bioscience | ||||||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||||||||||
| ISSN: | 1616-5187 | ||||||||||||||||||
| Official Date: | October 2019 | ||||||||||||||||||
| Dates: |
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| Volume: | 18 | ||||||||||||||||||
| Number: | 10 | ||||||||||||||||||
| Article Number: | 1800213 | ||||||||||||||||||
| DOI: | 10.1002/mabi.201800213 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | "This is the pre-peer reviewed version of the following article:Gurnani, Pratik, Sanchez-Cano, Carlos, Abraham, Kristin, Xandri-Monje, Helena, Cook, Alexander B., Hartlieb, Matthias, Lévi, Francis A., Dallmann, Robert and Perrier, Sébastien (2018) RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles. Macromolecular Bioscience. 1800213 which has been published in final form at http://dx.doi.org/10.1002/mabi.201800213 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Date of first compliant deposit: | 15 August 2018 | ||||||||||||||||||
| Date of first compliant Open Access: | 7 August 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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