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The dynamic roles of TGF-β signalling in EBV-associated cancers

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Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C. and Yap, Lee Fah (2018) The dynamic roles of TGF-β signalling in EBV-associated cancers. Cancers, 10 (8). 247. doi:10.3390/cancers10080247 ISSN 2072-6694.

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Official URL: https://doi.org/10.3390/cancers10080247

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Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Journal or Publication Title: Cancers
Publisher: MDPI
ISSN: 2072-6694
Official Date: 27 July 2018
Dates:
DateEvent
27 July 2018Published
25 July 2018Accepted
Volume: 10
Number: 8
Article Number: 247
DOI: 10.3390/cancers10080247
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 20 September 2018
Date of first compliant Open Access: 20 September 2018

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