Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C. and Yap, Lee Fah (2018) The dynamic roles of TGF-β signalling in EBV-associated cancers. Cancers, 10 (8). 247. doi:10.3390/cancers10080247

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Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School
SWORD Depositor:	Library Publications Router
Journal or Publication Title:	Cancers
Publisher:	MDPI
ISSN:	2072-6694
Official Date:	27 July 2018
Dates:	Date Event 27 July 2018 Published 25 July 2018 Accepted
Date of first compliant deposit:	20 September 2018
Volume:	10
Number:	8
Article Number:	247
DOI:	10.3390/cancers10080247
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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