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The dynamic roles of TGF-β signalling in EBV-associated cancers
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Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C. and Yap, Lee Fah (2018) The dynamic roles of TGF-β signalling in EBV-associated cancers. Cancers, 10 (8). 247. doi:10.3390/cancers10080247 ISSN 2072-6694.
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Official URL: https://doi.org/10.3390/cancers10080247
Abstract
The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | Cancers | ||||||
| Publisher: | MDPI | ||||||
| ISSN: | 2072-6694 | ||||||
| Official Date: | 27 July 2018 | ||||||
| Dates: |
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| Volume: | 10 | ||||||
| Number: | 8 | ||||||
| Article Number: | 247 | ||||||
| DOI: | 10.3390/cancers10080247 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 20 September 2018 | ||||||
| Date of first compliant Open Access: | 20 September 2018 |
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