English, Sarah, Steele, Amber, Williams, Alison, Blacklay, Jayne, Sorinola, Olanrewaju, Wernisch, Lorenz and Grammatopoulos, Dimitris (2018) Modelling of psychosocial and lifestyle predictors of peripartum depressive symptoms associated with distinct risk trajectories : a prospective cohort study. Scientific Reports, 8 . 12799 . doi:10.1038/s41598-018-30874-z

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Abstract

Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contribution to severity scores on the Edinburgh Postnatal Depression Scale (EPDS) screening tool. We determined depression risk trajectories in 480 women that prospectively completed the EPDS during pregnancy (TP1) and postpartum (TP2). Multinomial logistic and penalised linear regression investigated covariates associated with increased antenatal and postpartum EPDS scores contributing to the average or the difference of paired scores across time points. History of anxiety was identified as the strongest contribution to antenatal EPDS scores followed by the social status, whereas a history of depression, postpartum depression (PPD) and family history of PPD exhibited the strongest association with postpartum EPDS. These covariates were the strongest differentiating factors that increased the spread between antenatal and postpartum EPDS scores. Available covariates appeared better suited to predict EPDS scores antenatally than postpartum. As women move from the antenatal to the postpartum period, socio-demographic and lifestyle risk factors appear to play a smaller role in risk, and a personal and family history of depression and PPD become increasingly important.

Item Type:	Journal Article
Subjects:	R Medicine > RG Gynecology and obstetrics
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Postpartum depression, Postpartum depression -- Diagnosis, Edinburgh Postnatal Depression Scale , Postpartum depression -- Risk factors
Journal or Publication Title:	Scientific Reports
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Official Date:	24 August 2018
Dates:	Date Event 24 August 2018 Published 25 July 2018 Accepted
Date of first compliant deposit:	17 August 2018
Volume:	8
Article Number:	12799
DOI:	10.1038/s41598-018-30874-z
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	James Tudor Foundation, Warwick Collaborative Postgraduate Research Scholarshi
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED Innovate UK http://dx.doi.org/10.13039/501100006041 UNSPECIFIED South Warwickshire NHS Foundation Trust http://viaf.org/viaf/250963862 Impact award University of Warwick http://dx.doi.org/10.13039/501100000741 UNSPECIFIED Warwick Medical School http://dx.doi.org/10.13039/501100004443
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