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Modelling of psychosocial and lifestyle predictors of peripartum depressive symptoms associated with distinct risk trajectories : a prospective cohort study
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English, Sarah, Steele, Amber, Williams, Alison, Blacklay, Jayne, Sorinola, Olanrewaju, Wernisch, Lorenz and Grammatopoulos, Dimitris (2018) Modelling of psychosocial and lifestyle predictors of peripartum depressive symptoms associated with distinct risk trajectories : a prospective cohort study. Scientific Reports, 8 . 12799 . doi:10.1038/s41598-018-30874-z ISSN 2045-2322.
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WRAP-modelling-psychosocial-lifestyle-predictors-peripartum-depressive-symptoms-associated-distinct-risk-trajectories-Grammatopoulos-2018.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (903Kb) |
Official URL: https://doi.org/10.1038/s41598-018-30874-z
Abstract
Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contribution to severity scores on the Edinburgh Postnatal Depression Scale (EPDS) screening tool. We determined depression risk trajectories in 480 women that prospectively completed the EPDS during pregnancy (TP1) and postpartum (TP2). Multinomial logistic and penalised linear regression investigated covariates associated with increased antenatal and postpartum EPDS scores contributing to the average or the difference of paired scores across time points. History of anxiety was identified as the strongest contribution to antenatal EPDS scores followed by the social status, whereas a history of depression, postpartum depression (PPD) and family history of PPD exhibited the strongest association with postpartum EPDS. These covariates were the strongest differentiating factors that increased the spread between antenatal and postpartum EPDS scores. Available covariates appeared better suited to predict EPDS scores antenatally than postpartum. As women move from the antenatal to the postpartum period, socio-demographic and lifestyle risk factors appear to play a smaller role in risk, and a personal and family history of depression and PPD become increasingly important.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Postpartum depression, Postpartum depression -- Diagnosis, Edinburgh Postnatal Depression Scale , Postpartum depression -- Risk factors | |||||||||||||||
Journal or Publication Title: | Scientific Reports | |||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||
ISSN: | 2045-2322 | |||||||||||||||
Official Date: | 24 August 2018 | |||||||||||||||
Dates: |
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Volume: | 8 | |||||||||||||||
Article Number: | 12799 | |||||||||||||||
DOI: | 10.1038/s41598-018-30874-z | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 17 August 2018 | |||||||||||||||
Date of first compliant Open Access: | 19 September 2018 | |||||||||||||||
Funder: | James Tudor Foundation, Warwick Collaborative Postgraduate Research Scholarshi | |||||||||||||||
RIOXX Funder/Project Grant: |
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