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Deubiquitinating enzymes related to autophagy : new therapeutic opportunities?
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Jacomin, Anne-Claire, Taillebourg, Emmanuel and Fauvarque, Marie-Odile (2018) Deubiquitinating enzymes related to autophagy : new therapeutic opportunities? Cells, 7 . 112. doi:10.3390/cells7080112 ISSN 2073-4409.
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Official URL: https://doi.org/10.3390/cells7080112
Abstract
Autophagy is an evolutionary conserved catabolic process that allows for the degradation of intracellular components by lysosomes. This process can be triggered by nutrient deprivation, microbial infections or other challenges to promote cell survival under these stressed conditions. However, basal levels of autophagy are also crucial for the maintenance of proper cellular homeostasis by ensuring the selective removal of protein aggregates and dysfunctional organelles. A tight regulation of this process is essential for cellular survival and organismal health. Indeed, deregulation of autophagy is associated with a broad range of pathologies such as neuronal degeneration, inflammatory diseases, and cancer progression. Ubiquitination and deubiquitination of autophagy substrates, as well as components of the autophagic machinery, are critical regulatory mechanisms of autophagy. Here, we review the main evidence implicating deubiquitinating enzymes (DUBs) in the regulation of autophagy. We also discuss how they may constitute new therapeutic opportunities in the treatment of pathologies such as cancers, neurodegenerative diseases or infections.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Homeostasis, Cell organelles, Ubiquitin, Enzymes | ||||||||
| Journal or Publication Title: | Cells | ||||||||
| Publisher: | MDPI AG | ||||||||
| ISSN: | 2073-4409 | ||||||||
| Official Date: | 19 August 2018 | ||||||||
| Dates: |
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| Volume: | 7 | ||||||||
| Number of Pages: | 24 | ||||||||
| Article Number: | 112 | ||||||||
| DOI: | 10.3390/cells7080112 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 21 August 2018 | ||||||||
| Date of first compliant Open Access: | 21 August 2018 | ||||||||
| RIOXX Funder/Project Grant: |
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