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Advances toward diagnostic tools for managing zoonotic visceral leishmaniasis
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Duthie, Malcolm S., Lison, Aurore and Courtenay, Orin (2018) Advances toward diagnostic tools for managing zoonotic visceral leishmaniasis. Trends in Parasitology, 34 (10). pp. 881-890. doi:10.1016/j.pt.2018.07.012 ISSN 1471-4922.
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Official URL: http://dx.doi.org/10.1016/j.pt.2018.07.012
Abstract
Visceral leishmaniasis (VL) is a life-threatening outcome of Leishmania infantum or Leishmania donovani infection. Dogs are the primary domestic reservoir of L. infantum parasites, and ownership of infected dogs increases the risk of human VL. Controlling infection within dog populations is regarded as critical to VL management in endemic countries, both preventing progression of canine disease and limiting parasite transmission to humans and dogs. Here we discuss various strategies that are used to diagnose canine visceral leishmaniasis (CVL) and the possibilities of adapting these for use within population screening and control programs. In addition, given the variable transmissibility of L. infantum to the sand fly vector, we outline some possibilities for the preferential identification of ‘super-spreader’ dogs among the overall infected population.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Leishmaniasis, Dogs as carriers of disease, Dogs -- Diseases -- Treatment, Leishmaniasis -- Transmission -- Prevention, Leishmaniasis -- Diagnosis | ||||||||||||||||||
Journal or Publication Title: | Trends in Parasitology | ||||||||||||||||||
Publisher: | Elsevier Science | ||||||||||||||||||
ISSN: | 1471-4922 | ||||||||||||||||||
Official Date: | 1 October 2018 | ||||||||||||||||||
Dates: |
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Volume: | 34 | ||||||||||||||||||
Number: | 10 | ||||||||||||||||||
Page Range: | pp. 881-890 | ||||||||||||||||||
DOI: | 10.1016/j.pt.2018.07.012 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
Date of first compliant deposit: | 29 August 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 18 August 2019 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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