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Twelve weeks of supervised exercise improves self-reported symptom burden and fatigue in chronic kidney disease : a secondary analysis of the ‘ExTra CKD’ trial
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Wilkinson, Thomas J., Watson, Emma L., Gould, Douglas W., Xenophontos, Soteris, Clarke, Amy L., Vogt, Barbara P., Viana, João L. and Smith, Alice C. (2019) Twelve weeks of supervised exercise improves self-reported symptom burden and fatigue in chronic kidney disease : a secondary analysis of the ‘ExTra CKD’ trial. Clinical Kidney Journal, 12 (1). pp. 113-121. doi:10.1093/ckj/sfy071 ISSN 2048-8505.
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Official URL: http://dx.doi.org/10.1093/ckj/sfy071
Abstract
Background
Chronic kidney disease (CKD) patients experience a high symptom burden including fatigue, sleep difficulties, muscle weakness and pain. These symptoms reduce levels of physical function (PF) and activity, and contribute to poor health-related quality of life (HRQoL). Despite the gathering evidence of positive physiological changes following exercise in CKD, there is limited evidence on its effect on self-reported symptom burden, fatigue, HRQoL and physical activity.
Methods
Thirty-six patients [mean ± SD 61.6 ± 11.8 years, 22 (61%) females, estimated glomerular filtration rate: 25.5 ± 7.8 mL/min/1.73 m2] not requiring renal replacement therapy underwent 12 weeks (3 times/week) of supervised aerobic exercise (AE), or a combination (CE) of AE plus resistance training. Outcomes included self-reported symptom burden, fatigue, HRQoL and physical activity.
Results
Exercise reduced the total number of symptoms reported by 17% and had favourable effects on fatigue in both groups. AE reduced the frequency of ‘itching’, ‘impotence’ and ‘shortness of breath’ symptoms, and the intrusiveness for symptoms of ‘sleep disturbance’, ‘loss of muscular strength/power’, ‘muscle spasm/stiffness’ and ‘restless legs’. The addition of resistance exercise in the CE group saw a reduction in ‘loss of muscular strength/power’. No changes were seen in subjective PF or physical activity levels. AE increased self-efficacy for physical activity.
Conclusions
Supervised exercise had favourable effects on symptom frequency and intrusiveness, including substantial improvements in fatigue. Although the intervention did not improve self-reported physical activity levels, AE increased patients’ self-efficacy for physical activity. These favourable changes in self-reported outcomes support the important role of exercise in CKD.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Chronic renal failure -- Patients -- Sleep -- Statistics, Chronic renal failure -- Patients -- Exercise -- Statistics, Itching, Impotence, Dyspnea | ||||||||||||||||||
Journal or Publication Title: | Clinical Kidney Journal | ||||||||||||||||||
Publisher: | Oxford University Press | ||||||||||||||||||
ISSN: | 2048-8505 | ||||||||||||||||||
Official Date: | February 2019 | ||||||||||||||||||
Dates: |
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Volume: | 12 | ||||||||||||||||||
Number: | 1 | ||||||||||||||||||
Page Range: | pp. 113-121 | ||||||||||||||||||
DOI: | 10.1093/ckj/sfy071 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 4 September 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 4 September 2018 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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