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Measuring microtubule dynamics

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Zwetsloot, Alexander, Tut, Gokhan and Straube, Anne (2018) Measuring microtubule dynamics. Essays in Biochemistry . EBC20180035. doi:10.1042/EBC20180035 ISSN 0071-1365.

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Official URL: https://doi.org/10.1042/EBC20180035

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Abstract

Microtubules are key players in cellular self-organization, acting as structural scaffolds, cellular highways, force generators and signalling platforms. Microtubules are polar filaments that undergo dynamic instability, i.e. transition between phases of growth and shrinkage. This allows microtubules to explore the inner space of the cell, generate pushing and pulling forces and remodel themselves into arrays with different geometry and function such as the mitotic spindle. To do this, eukaryotic cells employ an arsenal of regulatory proteins to control microtubule dynamics spatially and temporally. Plants and microorganisms have developed secondary metabolites that perturb microtubule dynamics, many of which are in active use as cancer chemotherapeutics and anti-inflammatory drugs. Here we summarise the methods used to visualise microtubules and to measure the parameters of dynamic instability to study both microtubule regulatory proteins and the action of small molecules interfering with microtubule assembly and/or disassembly.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Microtubules
Journal or Publication Title: Essays in Biochemistry
Publisher: Portland Press Ltd.
ISSN: 0071-1365
Official Date: 4 October 2018
Dates:
DateEvent
4 October 2018Published
4 September 2018Accepted
Article Number: EBC20180035
DOI: 10.1042/EBC20180035
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Copyright Holders: The Author(s)
Date of first compliant deposit: 4 September 2018
Date of first compliant Open Access: 9 January 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/J003964/1 [MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
200870/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
RPG-2016-260Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
UNSPECIFIEDLister Institute of Preventive Medicinehttp://dx.doi.org/10.13039/501100001255
MR/N014294/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
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