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Measuring microtubule dynamics
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Zwetsloot, Alexander, Tut, Gokhan and Straube, Anne (2018) Measuring microtubule dynamics. Essays in Biochemistry . EBC20180035. doi:10.1042/EBC20180035 ISSN 0071-1365.
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Official URL: https://doi.org/10.1042/EBC20180035
Abstract
Microtubules are key players in cellular self-organization, acting as structural scaffolds, cellular highways, force generators and signalling platforms. Microtubules are polar filaments that undergo dynamic instability, i.e. transition between phases of growth and shrinkage. This allows microtubules to explore the inner space of the cell, generate pushing and pulling forces and remodel themselves into arrays with different geometry and function such as the mitotic spindle. To do this, eukaryotic cells employ an arsenal of regulatory proteins to control microtubule dynamics spatially and temporally. Plants and microorganisms have developed secondary metabolites that perturb microtubule dynamics, many of which are in active use as cancer chemotherapeutics and anti-inflammatory drugs. Here we summarise the methods used to visualise microtubules and to measure the parameters of dynamic instability to study both microtubule regulatory proteins and the action of small molecules interfering with microtubule assembly and/or disassembly.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Microtubules | ||||||||||||||||||
| Journal or Publication Title: | Essays in Biochemistry | ||||||||||||||||||
| Publisher: | Portland Press Ltd. | ||||||||||||||||||
| ISSN: | 0071-1365 | ||||||||||||||||||
| Official Date: | 4 October 2018 | ||||||||||||||||||
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| Article Number: | EBC20180035 | ||||||||||||||||||
| DOI: | 10.1042/EBC20180035 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Copyright Holders: | The Author(s) | ||||||||||||||||||
| Date of first compliant deposit: | 4 September 2018 | ||||||||||||||||||
| Date of first compliant Open Access: | 9 January 2019 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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