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Photochemical “in-air” combinatorial discovery of antimicrobial co-polymers
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Richards, Sarah-Jane, Jones, Adam, Tomás, Ruben M. F. and Gibson, Matthew I. (2018) Photochemical “in-air” combinatorial discovery of antimicrobial co-polymers. Chemistry - A European Journal, 24 (52). pp. 13758-13761. doi:10.1002/chem.201802594 ISSN 0947-6539.
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WRAP-photochemical-in-air-combinatorial-discovery-antimicrobial-co-polymers-Gibson-2018.pdf - Accepted Version - Requires a PDF viewer. Download (3499Kb) | Preview |
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Official URL: http://doi.org/10.1002/chem.201802594
Abstract
There is an urgent need to identify new, non‐traditional antimicrobials. The discovery of new polymeric antimicrobials is limited by current low‐throughput synthetic tools, which means that limited chemical space has been explored. Herein, we employ photochemical “in‐air” reversible addition–fragmentation chain‐transfer (RAFT) polymerization with microwell plates, using liquid‐handling robots to assemble large libraries of cationic polymers, without the need for degassing or purification steps, facilitating transfer to screening. Several lead polymers were identified including a co‐polymer with propylene glycol side chains with significantly enhanced antimicrobial activity and increased therapeutic window. Mechanistic studies showed that this polymer was bacteriostatic, and surprisingly did not lyse the cell membranes, implying an alternative mode of action. This versatile method using simple robotics will help to develop new biomaterials with emergent properties.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Journal or Publication Title: | Chemistry - A European Journal | ||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
ISSN: | 0947-6539 | ||||||||
Official Date: | 18 September 2018 | ||||||||
Dates: |
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Volume: | 24 | ||||||||
Number: | 52 | ||||||||
Page Range: | pp. 13758-13761 | ||||||||
DOI: | 10.1002/chem.201802594 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article:S.-J. Richards, A. Jones, R. M. F. Tomás, M. I. Gibson, Chem. Eur. J. 2018, 24, 13758. which has been published in final form at http://doi.org/10.1002/chem.201802594 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 11 September 2018 | ||||||||
Date of first compliant Open Access: | 9 January 2019 |
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