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Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours
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Manias, Karen A., Harris, Lisa M., Davies, Nigel P., Natarajan, Kal, MacPherson, Lesley, Foster, Katharine, Brundler, Marie-Anne, Hargrave, Darren R., Payne, Geoffery S., Leach, Martin O., Morgan, Paul S., Auer, Dorothee P., Jaspan, Tim, Arvanitis, Theodoros N., Grundy, Richard G. and Peet, Andrew C. (2018) Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours. Pediatric Radiology, 48 (11). pp. 1630-1641. doi:10.1007/s00247-018-4182-0
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WRAP-prospective-evaluation-analysis-magnetic-childhood-tumours-Arvanitis-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1658Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/s00247-018-4182-0
Abstract
AbstractBackgroundA tool for diagnosing childhood cerebellar tumours using magnetic resonance (MR) spectroscopy peak height measurement has been developed based on retrospective analysis of single-centre data.ObjectiveTo determine the diagnostic accuracy of the peak height measurement tool in a multicentre prospective study, and optimise it by adding new prospective data to the original dataset.Materials and methodsMagnetic resonance imaging (MRI) and single-voxel MR spectroscopy were performed on children with cerebellar tumours at three centres. Spectra were processed using standard scanner software and peak heights for N-acetyl aspartate, creatine, total choline and myo-inositol were measured. The original diagnostic tool was used to classify 26 new tumours as pilocytic astrocytoma, medulloblastoma or ependymoma. These spectra were subsequently combined with the original dataset to develop an optimised scheme from 53 tumours in total.ResultsOf the pilocytic astrocytomas, medulloblastomas and ependymomas, 65.4% were correctly assigned using the original tool. An optimized scheme was produced from the combined dataset correctly assigning 90.6%. Rare tumour types showed distinctive MR spectroscopy features.ConclusionThe original diagnostic tool gave modest accuracy when tested prospectively on multicentre data. Increasing the dataset provided a diagnostic tool based on MR spectroscopy peak height measurement with high levels of accuracy for multicentre data.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Journal or Publication Title: | Pediatric Radiology | ||||||||
| Publisher: | Springer Berlin Heidelberg | ||||||||
| ISSN: | 1432-1998 | ||||||||
| Official Date: | October 2018 | ||||||||
| Dates: |
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| Volume: | 48 | ||||||||
| Number: | 11 | ||||||||
| Page Range: | pp. 1630-1641 | ||||||||
| DOI: | 10.1007/s00247-018-4182-0 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Publisher Statement: | ** From Springer Nature via Jisc Publications Router. ** History: received 21-08-2017; rev-recd 10-05-2018; accepted 10-06-2018; epub 30-07-2018; ppub 10-2018. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ | ||||||||
| Access rights to Published version: | Open Access | ||||||||
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