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Mutagenicity potential (affect) of new atraumatic restorative treatment (ART) material incorporated with Azadirachta indica (Neem) against Salmonella typhimurium
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Divya Kumari, P., Shetty, A. Veena, Khijmatgar, Shahnawaz, Chowdhury, Avidyuti, Lynch, Edward, Dr. and Chowdhury, Chitta R. (2019) Mutagenicity potential (affect) of new atraumatic restorative treatment (ART) material incorporated with Azadirachta indica (Neem) against Salmonella typhimurium. Journal of Oral Biology and Craniofacial Research, 9 (1). pp. 5-9. doi:10.1016/j.jobcr.2018.08.003 ISSN 2212-4268.
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Official URL: http://dx.doi.org/10.1016/j.jobcr.2018.08.003
Abstract
Background
The mutagenicity potential of a new atraumatic restorative treatment (ART) material against Salmonella typhimurium without metabolic activity using the Ames test (genotoxicity) was carried out.
Methods and materials
The potential mutagenicity of new atraumatic restorative treatment materials (ART-I and ART-II) was analyzed using the Ames test. The materials were eluted in dimethyl sulphoxide, 0.9% NaCl solution and sterilized de-ionized water and the aliquots were used after an incubation period of 24 h at 37 °C. Mutagenic effects of the materials were tested on Salmonella typhimurium strains TA 98 and TA 100 using the standard assay, and in absence of S9 fraction from rat liver.
Result
No mutagenic effects were detected for these new ART materials on S. typhimurium TA100. The incubated DMSO extract and 0.9% NaCl extract (50 μl/plate) of the ART-I exhibited a weak mutagenic potential on S. typhimurium TA 98. In particular, Aqua extract (50 μl/plate) of ART-II, was associated with a weak mutagenic potential on S. typhimurium TA98.
Conclusion
Both ART materials (ART–I and II) exhibited weak mutagenic effects on S. typhimurium TA98 whereas no mutagenic effect was detected on S. typhimurium TA100. ART-II is safer than ART-I.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Journal or Publication Title: | Journal of Oral Biology and Craniofacial Research | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 2212-4268 | ||||||||
| Official Date: | January 2019 | ||||||||
| Dates: |
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| Volume: | 9 | ||||||||
| Number: | 1 | ||||||||
| Page Range: | pp. 5-9 | ||||||||
| DOI: | 10.1016/j.jobcr.2018.08.003 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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