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Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf
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UNSPECIFIED (2002) Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf. VETERINARY PARASITOLOGY, 105 (4). pp. 285-301.
Full text not available from this repository, contact author.Abstract
Infection with the bovine abomasal nematode, Ostertagia ostertagi, results in a loss of acid-secreting parietal cells and an increase in gastric pH. The effects of an experimental infection with Ostertagia and/or daily treatment with omeprazole (OMP) at 2 mg kg(-1) bodyweight for four consecutive days (experiment days 24-27, inclusive) on voluntary feed intake, blood and tissue gastrin concentrations, abomasal G-cell numbers, gastric pH, and blood cholecystokinin (CCK) and pepsinogen concentrations were investigated in the calf. Ostertagia-infected calves demonstrated a significant drop in feed intake between days 24 and 27 post-infection (38%; P < 0.001) and in G-cell numbers (42%; P < 0.05) and significant increases in abomasal pH (P < 0.001), fundic mucosal weight (99%; P < 0.01), and blood gastrin (P < 0.05) and pepsinogen (P < 0.0001). OMP treatment of worm-free animals resulted in a significant drop in intake between days 24 and 27 (30%; P < 0.001) and in G-cell numbers (17%; P < 0.05) and significant increases in abomasal pH (P < 0.01) and blood gastrin (P < 0.001). OMP treatment of Ostertagia-infected animals with an existing hypergastrinaemia had no effect on feed intake, abomasal pH, blood gastrin or pepsinogen or abomasal G-cell numbers. Blood CCK concentrations were also unaffected by either Ostertagia infection or OMP treatment. These data suggest that: (a) the depression in feed intake associated with OMP in worm-free calves was not due to a side effect of drug treatment; (b) inappetance in Ostertagia-infected animals is closely associated with the parasite-induced hypergastrinaemia; and (c) the elevation in abomasal pH was a major factor responsible for the elevated blood gastrin concentrations seen in parasitised and OMP-treated animals. (C) 2002 Elsevier Science B.V. All rights reserved.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QL Zoology S Agriculture > SF Animal culture |
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| Journal or Publication Title: | VETERINARY PARASITOLOGY | ||||
| Publisher: | ELSEVIER SCIENCE BV | ||||
| ISSN: | 0304-4017 | ||||
| Official Date: | 10 May 2002 | ||||
| Dates: |
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| Volume: | 105 | ||||
| Number: | 4 | ||||
| Number of Pages: | 17 | ||||
| Page Range: | pp. 285-301 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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