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The pseudomonas aeruginosa Type VI secretion PGAP1-like effector induces host autophagy by activating endoplasmic reticulum stress
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Jiang, Feng, Wang, Xia, Wang, Bei, Chen, Lihong, Zhao, Zhendong, Waterfield, Nicholas R., Yang, Guowei and Jin, Qi (2016) The pseudomonas aeruginosa Type VI secretion PGAP1-like effector induces host autophagy by activating endoplasmic reticulum stress. Cell Reports, 16 (6). pp. 1502-1509. doi:10.1016/j.celrep.2016.07.012 ISSN 2211-1247.
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Official URL: http://dx.doi.org/10.1016/j.celrep.2016.07.012
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that regularly causes nosocomial infections in hospitalized patients. The type VI secretion system (T6SS) is responsible for the secretion of numerous virulence effector proteins that can both interfere with competing microbes and manipulate host cells. Here, we report a detailed investigation of a P. aeruginosa H2-T6SS-dependent phospholipase effector, TplE, which acts as a trans-kingdom toxin. Delivery of TplE to the periplasmic space of rival bacteria leads to growth inhibition. Importantly, TplE, also contains a eukaryotic PGAP1-like domain, which targets the host ER apparatus, ultimately leading to disruption of the ER. TplE activity leads to the activation of the unfolded protein response (UPR) through the IRE1α-XBP1 pathway, enhancing autophagic flux. These findings indicate that this T6SS-delivered phospholipase effector is active against both prokaryotic and eukaryotic cellular targets, highlighting the T6SS as a versatile weapon in the Pseudomonas arsenal.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Pseudomonas aeruginosa infections -- Prevention, Prokaryotes, Eukaryotic cells | ||||||||||||||||||
Journal or Publication Title: | Cell Reports | ||||||||||||||||||
Publisher: | Elsevier Inc. | ||||||||||||||||||
ISSN: | 2211-1247 | ||||||||||||||||||
Official Date: | 9 August 2016 | ||||||||||||||||||
Dates: |
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Volume: | 16 | ||||||||||||||||||
Number: | 6 | ||||||||||||||||||
Page Range: | pp. 1502-1509 | ||||||||||||||||||
DOI: | 10.1016/j.celrep.2016.07.012 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 21 September 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 21 September 2018 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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