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Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria
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(2018) Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria. Scientific Reports, 8 (1). 14194 . doi:10.1038/s41598-018-32475-2 ISSN 2045-2322.
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Official URL: http://dx.doi.org/10.1038/s41598-018-32475-2
Abstract
After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Library of Congress Subject Headings (LCSH): | Neisseria meningitidis, Meningitis -- Nigeria, Epidemics -- Nigeria | ||||||
Journal or Publication Title: | Scientific Reports | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 2045-2322 | ||||||
Official Date: | 21 September 2018 | ||||||
Dates: |
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Volume: | 8 | ||||||
Number: | 1 | ||||||
Article Number: | 14194 | ||||||
DOI: | 10.1038/s41598-018-32475-2 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 24 September 2018 | ||||||
Date of first compliant Open Access: | 25 September 2018 |
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