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Selectivity studies of the benzene cis-dihydrodiol dehydrogenase enzyme from Pseudomonas putida ML2 with Vicinal diol substrates

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UNSPECIFIED (2002) Selectivity studies of the benzene cis-dihydrodiol dehydrogenase enzyme from Pseudomonas putida ML2 with Vicinal diol substrates. BIOCATALYSIS AND BIOTRANSFORMATION, 20 (4). pp. 257-264. doi:10.1080/10242420290029454

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Official URL: http://dx.doi.org/10.1080/10242420290029454

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Abstract

The enantiopure (1S, 2S)-cis-dihydrodiol metabolites 2B-5B have been obtained in low yield from the corresponding monosubstituted halobenzene substrates 2A-5A, using a wild-type strain of Pseudomonas putida (ML2) containing benzene dioxygenase (BDO). Benzene cis-dihydrodiol dehydrogenase (BCD) from P. putida ML2 and naphthalene cis-dihydrodiol dehydrogenase (NCD) from P. putida 8859 were purified and used in a comparative study of the stereoselective biotransformation of cis-dihydrodiol enantiomers 2B-5B. The BCD and NCD enzymes were found to accept cis-dihydrodiol enantiomers of monosubstituted benzene cis-dihydrodiol substrates 2B-5B of opposite absolute configuration. The acyclic alkene 1,2-diols 10-17 were also found to be acceptable substrates for BCD.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Journal or Publication Title: BIOCATALYSIS AND BIOTRANSFORMATION
Publisher: TAYLOR & FRANCIS LTD
ISSN: 1024-2422
Official Date: August 2002
Dates:
DateEvent
August 2002UNSPECIFIED
Volume: 20
Number: 4
Number of Pages: 8
Page Range: pp. 257-264
DOI: 10.1080/10242420290029454
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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