The Library
A model describing the multiphasic dynamics of mixed meal glucose responses in healthy subjects
Tools
Eichenlaub, Manuel, Khovanova, N. A. and Hattersley, John (2018) A model describing the multiphasic dynamics of mixed meal glucose responses in healthy subjects. In: Lhotska, L. and Sukupova, L. and Lacković , I. and Ibbott, G., (eds.) World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, 68/1 . Singapore: Springer, pp. 577-581. ISBN 9789811090349
|
PDF
WRAP-model-describing-multiphasic-dynamics-mixed-meal-glucose-Khovanova-2018.pdf - Accepted Version - Requires a PDF viewer. Download (495Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/978-981-10-9035-6_107
Abstract
Modelling of the glucose metabolism for the purpose of improving the diagnosis and therapy of diabetes mellitus has been the subject of research for decades. Despite this effort, conventional models describing postprandial glucose profiles of healthy subjects fail to include the phenomenon of biphasic glucose responses. Continuous glucose monitoring data recorded from five healthy subjects show that mono- and biphasic glucose responses from regular meals are equally common. We therefore developed a suitable parametric model, capable of producing mono- as well as biphasic meal responses. It is expressed by linear second order differential equation with a dual Gaussian input function. Additionally, a simple method for classifying meal responses into mono- or biphasic profiles was developed. Model inversion was performed using a fully Bayesian method. R2 values of model output compared to CGM data was 91.6 ± 8.3%, indicating the models ability of accurately describing a wide range of mixed meal glucose responses. Parameters were found to be associated with characteristics of individual meals. We suggest that the model could be used to objectively assess postprandial hyperglycemia, one of the main measures for glycemic control.
Item Type: | Book Item | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
Library of Congress Subject Headings (LCSH): | Diabetes -- Patients, Glucose, Metabolism | ||||||
Series Name: | IFMBE Proceedings | ||||||
Publisher: | Springer | ||||||
Place of Publication: | Singapore | ||||||
ISBN: | 9789811090349 | ||||||
ISSN: | 1680-0737 | ||||||
Book Title: | World Congress on Medical Physics and Biomedical Engineering 2018 | ||||||
Editor: | Lhotska, L. and Sukupova, L. and Lacković , I. and Ibbott, G. | ||||||
Official Date: | 30 May 2018 | ||||||
Dates: |
|
||||||
Volume: | 68/1 | ||||||
Page Range: | pp. 577-581 | ||||||
DOI: | 10.1007/978-981-10-9035-6_107 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 25 September 2018 | ||||||
Date of first compliant Open Access: | 30 May 2019 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year