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Data for Multivalent presentation of ice recrystallization inhibiting polymers on nanoparticles retains activity
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Stubbs, Christopher D. (David), Wilkins, Laura E., Fayter, Alice, Walker, Marc and Gibson, Matthew I. (2018) Data for Multivalent presentation of ice recrystallization inhibiting polymers on nanoparticles retains activity. [Dataset]
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Data 109058.zip - Unspecified Version Available under License Creative Commons Attribution 4.0. Download (11Mb) |
Official URL: http://wrap.warwick.ac.uk/109058
Abstract
Poly(vinyl alcohol) (PVA) has emerged as the most potent mimic of antifreeze (glyco)proteins ice recrystallization inhibition (IRI) activity, despite its lack of structural similarities and flexible, rather than rigid, backbone. The precise spacing of hydroxyl groups is hypothesized to enable PVA to recognize the prism planes of ice but not the basal plane, due to hydroxyl pattern matching of the ice surface giving rise to the macroscopic activity. Here, well-defined PVA derived from reversible addition–fragmentation chain-transfer (RAFT) polymerization is immobilized onto gold nanoparticles to enable the impact of nanoscale assembly and confinement on the observed IRI activity. Unlike previous reports using star-branched or bottle-brush PVAs, the nanoparticle–PVA retains all IRI activity compared to polymers in solution. Evidence is presented to show that this is due to the low grafting densities on the particle surface meaning the chains are free to explore the ice faces, rather than being constrained as in star-branched polymers. These results demonstrate a route to develop more functional IRI’s and inclusion of metallic particle cores for imaging and associated applications in cryobiology.
Item Type: | Dataset | |||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Type of Data: | Zip | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Polyvinyl alcohol, Vinyl polymers, Hydroxyl group, Antifreeze proteins, Nanoparticles | |||||||||||||||
Journal or Publication Title: | Langmuir | |||||||||||||||
Publisher: | University of Warwick, Department of Chemistry | |||||||||||||||
ISSN: | 0743-7463 | |||||||||||||||
Official Date: | 10 August 2018 | |||||||||||||||
Dates: |
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DOI: | 10.1021/acs.langmuir.8b01952 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Copyright Holders: | University of Warwick | |||||||||||||||
Date of first compliant deposit: | 2 October 2018 | |||||||||||||||
Date of first compliant Open Access: | 2 October 2018 | |||||||||||||||
RIOXX Funder/Project Grant: |
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