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Reconstructing the ancestral relationships between bacterial pathogen genomes
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Collins, Caitlin and Didelot, Xavier (2016) Reconstructing the ancestral relationships between bacterial pathogen genomes. In: Nordenfelt, P. and Collin, M., (eds.) Bacterial Pathogenesis. Springer, pp. 109-137. ISBN 9781493966714
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Official URL: http://dx.doi.org/10.1007/978-1-4939-6673-8_8
Abstract
Following recent developments in DNA sequencing technology, it is now possible to sequence hundreds of whole genomes from bacterial isolates at relatively low cost. Analyzing this growing wealth of genomic data in terms of ancestral relationships can reveal many interesting aspects of the evolution, ecology, and epidemiology of bacterial pathogens. However, reconstructing the ancestry of a sample of bacteria remains challenging, especially for the majority of species where recombination is frequent. Here, we review and describe the computational techniques currently available to infer ancestral relationships, including phylogenetic methods that either ignore or account for the effect of recombination, as well as model-based and model-free phylogeny-independent approaches.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Bacterial Pathogenesis | ||||
| Publisher: | Springer | ||||
| ISBN: | 9781493966714 | ||||
| ISSN: | 1064-3745 | ||||
| Book Title: | Bacterial Pathogenesis | ||||
| Editor: | Nordenfelt, P. and Collin, M. | ||||
| Official Date: | 3 December 2016 | ||||
| Dates: |
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| Volume: | 1535 | ||||
| Page Range: | pp. 109-137 | ||||
| DOI: | 10.1007/978-1-4939-6673-8_8 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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