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Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
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Eldholm, Vegard, Rieux, Adrien, Monteserin, Johana, Lopez, Julia Montana, Palmero, Domingo, Lopez, Beatriz, Ritacco, Viviana, Didelot, Xavier and Balloux, Francois (2016) Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis. eLife, 5 . doi:10.7554/eLife.16644 ISSN 2050-084X.
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Official URL: http://dx.doi.org/10.7554/eLife.16644
Abstract
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | eLife | ||||||
Publisher: | eLife Sciences Publications Ltd. | ||||||
ISSN: | 2050-084X | ||||||
Official Date: | 9 August 2016 | ||||||
Dates: |
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Volume: | 5 | ||||||
DOI: | 10.7554/eLife.16644 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
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