The Library
Tetracycline selective pressure and homologous recombination shape the evolution of Chlamydia suis : a recently identified zoonotic pathogen
Tools
Tools
Tools
Joseph, Sandeep J., Marti, Hanna, Didelot, Xavier, Read, Timothy D. and Dean, Deborah (2016) Tetracycline selective pressure and homologous recombination shape the evolution of Chlamydia suis : a recently identified zoonotic pathogen. Genome Biology and Evolution, 8 (8). pp. 2613-2623. doi:10.1093/gbe/evw182
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1093/gbe/evw182
Abstract
Species closely related to the human pathogen Chlamydia trachomatis (Ct) have recently been found to cause zoonotic infections, posing a public health threat especially in the case of tetracycline resistant Chlamydia suis (Cs) strains. These strains acquired a tet(C)-containing cassette via horizontal gene transfer (HGT). Genomes of 11 Cs strains from various tissues were sequenced to reconstruct evolutionary pathway(s) for tet(C) HGT. Cs had the highest recombination rate of Chlamydia species studied to date. Admixture occurred among Cs strains and with Chlamydia muridarum but not with Ct. Although in vitro tet(C) cassette exchange with Ct has been documented, in vivo evidence may require examining human samples from Ct and Cs co-infected sites. Molecular-clock dating indicated that ancestral clades of resistant Cs strains predated the 1947 discovery of tetracycline, which was subsequently used in animal feed. The cassette likely spread throughout Cs strains by homologous recombination after acquisition from an external source, and our analysis suggests Betaproteobacteria as the origin. Selective pressure from tetracycline may be responsible for recent bottlenecks in Cs populations. Since tetracycline is an important antibiotic for treating Ct, zoonotic infections at mutual sites of infection indicate the possibility for cassette transfer and major public health repercussions.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Genome Biology and Evolution | ||||||||
| Publisher: | Oxford University Press | ||||||||
| ISSN: | 1759-6653 | ||||||||
| Official Date: | 1 August 2016 | ||||||||
| Dates: |
|
||||||||
| Volume: | 8 | ||||||||
| Number: | 8 | ||||||||
| Page Range: | pp. 2613-2623 | ||||||||
| DOI: | 10.1093/gbe/evw182 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
