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Declaring a tuberculosis outbreak over with genomic epidemiology
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Hatherell, Hollie-Ann, Tang, Patrick, Pollock, Sue L., Didelot, Xavier, Johnston, James C., Gardy, Jennifer L., Crisan, Anamaria and Colijn, Caroline (2016) Declaring a tuberculosis outbreak over with genomic epidemiology. Microbial Genomics, 2 (5). doi:10.1099/mgen.0.000060 ISSN 2057-5858.
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Official URL: http://dx.doi.org/10.1099/mgen.0.000060
Abstract
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Microbial Genomics | ||||||
Publisher: | Microbiology Society | ||||||
ISSN: | 2057-5858 | ||||||
Official Date: | 31 May 2016 | ||||||
Dates: |
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Volume: | 2 | ||||||
Number: | 5 | ||||||
DOI: | 10.1099/mgen.0.000060 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
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