Montano, Valeria, Didelot, Xavier, Foll, Matthieu, Linz, Bodo, Reinhardt, Richard, Suerbaum, Sebastian, Moodley, Yoshan and Jensen, Jeffrey D. (2015) Worldwide population structure, long-term demography, and local adaptation of Helicobacter pylori. Genetics, 200 (3). pp. 947-963. doi:10.1534/genetics.115.176404

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Abstract

Helicobacter pylori is an important human pathogen associated with serious gastric diseases. Owing to its medical importance and close relationship with its human host, understanding genomic patterns of global and local adaptation in H. pylori may be of particular significance for both clinical and evolutionary studies. Here we present the first such whole genome analysis of 60 globally distributed strains, from which we inferred worldwide population structure and demographic history and shed light on interesting global and local events of positive selection, with particular emphasis on the evolution of San-associated lineages. Our results indicate a more ancient origin for the association of humans and H. pylori than previously thought. We identify several important perspectives for future clinical research on candidate selected regions that include both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis factor alpha-inducing protein Tipα) and hitherto unknown functional genes.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Genetics
Publisher:	Genetics Society of America
ISSN:	0016-6731
Official Date:	July 2015
Dates:	Date Event July 2015 Published 15 May 2015 Accepted
Volume:	200
Number:	3
Page Range:	pp. 947-963
DOI:	10.1534/genetics.115.176404
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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