The Library
Population structure of Neisseria gonorrhoeaebased on whole genome data and its relationship with antibiotic resistance
Tools
Tools
Tools
Ezewudo, Matthew N., Joseph, Sandeep J., Castillo-Ramirez, Santiago, Dean, Deborah, del Rio, Carlos, Didelot, Xavier, Dillon, Jo-Anne, Selden, Richard F., Shafer, William M., Turingan, Rosemary S., Unemo, Magnus and Read, Timothy D. (2015) Population structure of Neisseria gonorrhoeaebased on whole genome data and its relationship with antibiotic resistance. PeerJ, 3 . e806. doi:10.7717/peerj.806
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.7717/peerj.806
Abstract
Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. The population structure and evolutionary forces within the pathogen population were analyzed. Our results indicated a cosmopolitan gonoccocal population mainly made up of five subgroups. The estimated ratio of recombination to mutation (r/m = 2.2) from our data set indicates an appreciable level of recombination occurring in the population. Strains with resistance phenotypes to more recent antibiotics (azithromycin and cefixime) were mostly found in two of the five population subgroups.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | PeerJ | ||||||
| Publisher: | PeerJ, Ltd. | ||||||
| ISSN: | 2167-8359 | ||||||
| Official Date: | 8 February 2015 | ||||||
| Dates: |
|
||||||
| Volume: | 3 | ||||||
| Article Number: | e806 | ||||||
| DOI: | 10.7717/peerj.806 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
