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Recombination shapes genome architecture in an organism from the archaeal domain
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Krause, David J., Didelot, Xavier, Cadillo-Quiroz, Hinsby and Whitaker, Rachel J. (2014) Recombination shapes genome architecture in an organism from the archaeal domain. Genome Biology and Evolution, 6 (1). pp. 170-178. doi:10.1093/gbe/evu003 ISSN 1759-6653.
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Official URL: http://dx.doi.org/10.1093/gbe/evu003
Abstract
Variation in recombination rates across chromosomes has been shown to be a primary force shaping the architecture of genome divergence. In archaea, little is known about variation in recombination across the chromosome or how it shapes genome evolution. We identified significant variations in polymorphism occurring across the chromosomes of ten closely related sympatric strains of the thermoacidophilic archaeon Sulfolobus islandicus. Statistical analyses show that recombination varies across the genome and interacts with selection to define large genomic regions with reduced polymorphism, particularly in the regions surrounding the three origins of replication. Our findings demonstrate how recombination defines the mosaic of variation in this asexually reproducing microorganism and provide insight into the evolutionary origins of genome architecture in this organism from the Archaeal domain.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Genome Biology and Evolution | ||||||
Publisher: | Oxford University Press | ||||||
ISSN: | 1759-6653 | ||||||
Official Date: | 3 January 2014 | ||||||
Dates: |
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Volume: | 6 | ||||||
Number: | 1 | ||||||
Page Range: | pp. 170-178 | ||||||
DOI: | 10.1093/gbe/evu003 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
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