The Library
Coordination cages based on bis(pyrazolyl-pyridine) ligands : structures, dynamic behavior, guest binding and catalysis
Tools
Ward, Michael D., Hunter, Christopher A. and Williams, Nicholas H. (2018) Coordination cages based on bis(pyrazolyl-pyridine) ligands : structures, dynamic behavior, guest binding and catalysis. Accounts of Chemical Research, 51 (9). pp. 2073-2082. doi:10.1021/acs.accounts.8b00261 ISSN 0001-4842.
|
PDF
WRAP-coordination-cages-based-ligands-dynamic-catalysis-Ward-2018.pdf - Accepted Version - Requires a PDF viewer. Download (16Mb) | Preview |
Official URL: https://doi.org/10.1021/acs.accounts.8b00261
Abstract
We describe here a family of coordination cages with interesting structural, guest-binding and catalytic properties. Flexible bridging ligands containing two bidentate pyrazolyl-pyridine termini assemble with transition metal dications to afford coordination cages containing a metal ion at each vertex, a bridging ligand spanning each edge, and a 2:3 metal:ligand ratio. This stoichiometry is expressed in structures ranging from M4L6 tetrahedra to M16L24 tetra-capped truncated tetrahedral, which are stabilised by formation of π-stacked arrays between electron-rich and electron-poor ligand segments which form around the cage periphery. In some cases concentration and/or temperature-dependent equilibria between multiple cage structures occur arising from a balance between entropy, which favours formation of a larger number of smaller assemblies, and enthalpy, which maximises both inter-ligand aromatic stacking and solvophobic effects in the larger assembles.
The cages are hollow and can accommodate guests – often anions or solvent molecules – in the central cavity. For one cage family, M8L12 species with an approximately cubic structure and a ca. 400 Å3 cavity, the guest binding properties have been studied extensively. This cage can accommodate a wide range of neutral organic guests, with binding in water being driven principally by the hydrophobic effect which leads to binding constants of up to 108 M-1. The accumulation of a large amount of empirical data on guest binding in the M8L12 cage in water provided the basis of a predictive tool for in silico screening of potential guests using the molecular docking programme GOLD; this methodology has allowed identification of numerous new guests with accurately predicted binding constants and provides a transformative new approach to exploring the host/guest chemistry of cages.
Binding of benzisoxazole inside the M8L12 cage results in substantial rate enhancements – by a factor of up to 2 x 105 – of the Kemp elimination in which benzisoxazole reacts to give 2-cyanophenolate. Catalysis arises because the 16+ cage cation accumulates anions around the surface by ion-pairing, leading to a high effective concentration of hydroxide ions surrounding the guest even when the bulk pH is modest. Thus the catalysis relies on operation of two orthogonal interactions which bring the reaction partners together: hydrophobic guest binding in the cavity which is lined with CH groups from the ligands, and ion pairing around the highly cationic cage surface. A consequence of this is that under some conditions the product of the cage-catalysed Kemp elimination (the 2-cyanophenolate anion) itself accumulates around the cage surface and deprotonates another benzisoxazole guest, perpetuating the reaction in an autocatalytic manner. Thus, different anions accumulating around the cage can act as partners for reaction with a cavity-bound guest, opening up the possibility of the M8L12 cage being able to act as a general catalyst for reactions of electrophilic guests with surface-bound anions.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QC Physics Q Science > QD Chemistry |
||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Coordination compounds, Ligands, Anions, Solvents -- Molecular aspects, Catalysis | ||||||||
Journal or Publication Title: | Accounts of Chemical Research | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 0001-4842 | ||||||||
Official Date: | 18 September 2018 | ||||||||
Dates: |
|
||||||||
Volume: | 51 | ||||||||
Number: | 9 | ||||||||
Page Range: | pp. 2073-2082 | ||||||||
DOI: | 10.1021/acs.accounts.8b00261 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 5 October 2018 | ||||||||
Date of first compliant Open Access: | 7 August 2019 | ||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year