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Genomic characterization of the Bacillus cereus sensu lato species : backdrop to the evolution of Bacillus anthracis
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Zwick, M. E., Joseph, S. J., Didelot, Xavier, Chen, P. E., Bishop-Lilly, K. A., Stewart, A. C., Willner, K., Nolan, N., Lentz, S., Thomason, M. K., Sozhamannan, S., Mateczun, A. J., Du, L. and Read, T. D. (2012) Genomic characterization of the Bacillus cereus sensu lato species : backdrop to the evolution of Bacillus anthracis. Genome Research, 22 (8). pp. 1512-1524. doi:10.1101/gr.134437.111 ISSN 1088-9051.
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Official URL: http://dx.doi.org/10.1101/gr.134437.111
Abstract
The key genes required for Bacillus anthracis to cause anthrax have been acquired recently by horizontal gene transfer. To understand the genetic background for the evolution of B. anthracis virulence, we obtained high-redundancy genome sequences of 45 strains of the Bacillus cereus sensu lato (s.l.) species that were chosen for their genetic diversity within the species based on the existing multilocus sequence typing scheme. From the resulting data, we called more than 324,000 new genes representing more than 12,333 new gene families for this group. The core genome size for the B. cereus s.l. group was ∼1750 genes, with another 2150 genes found in almost every genome constituting the extended core. There was a paucity of genes specific and conserved in any clade. We found no evidence of recent large-scale gene loss in B. anthracis or for unusual accumulation of nonsynonymous DNA substitutions in the chromosome; however, several B. cereus genomes isolated from soil and not previously associated with human disease were degraded to various degrees. Although B. anthracis has undergone an ecological shift within the species, its chromosome does not appear to be exceptional on a macroscopic scale compared with close relatives.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Genome Research | ||||
Publisher: | Cold Spring Harbor Lab Press | ||||
ISSN: | 1088-9051 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | 22 | ||||
Number: | 8 | ||||
Page Range: | pp. 1512-1524 | ||||
DOI: | 10.1101/gr.134437.111 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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