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Mismatch induced speciation in Salmonella : model and data
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Falush, D., Torpdahl, M., Didelot, Xavier, Conrad, D. F., Wilson, D. J. and Achtman, Mark (2006) Mismatch induced speciation in Salmonella : model and data. Philosophical Transactions of the Royal Society B: Biological Sciences, 361 (1475). pp. 2045-2053. doi:10.1098/rstb.2006.1925 ISSN 0962-8436.
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Official URL: http://dx.doi.org/10.1098/rstb.2006.1925
Abstract
In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations which show that the homology dependence of recombination can cause de novo speciation in a neutrally evolving population once a critical population size has been exceeded. Our model can explain the patterns of divergence and genetic exchange observed in the genus Salmonella, without invoking either natural selection or geographical population subdivision. If this model was validated, based on extensive sequence data, it would imply that the named subspecies of Salmonella enterica correspond to good biological species, making species boundaries objective. However, multilocus sequence typing data, analysed using several conventional tools, provide a misleading impression of relationships within S. enterica subspecies enterica and do not provide the resolution to establish whether new species are presently being formed.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Philosophical Transactions of the Royal Society B: Biological Sciences | ||||||
| Publisher: | The Royal Society Publishing | ||||||
| ISSN: | 0962-8436 | ||||||
| Official Date: | 29 November 2006 | ||||||
| Dates: |
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| Volume: | 361 | ||||||
| Number: | 1475 | ||||||
| Page Range: | pp. 2045-2053 | ||||||
| DOI: | 10.1098/rstb.2006.1925 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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