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Engineering CRISPR guide RNA riboswitches for in vivo applications

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Galizi, Roberto and Jaramillo, Alfonso (2019) Engineering CRISPR guide RNA riboswitches for in vivo applications. Current Opinion in Biotechnology, 55 . pp. 103-113. doi:10.1016/j.copbio.2018.08.007

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Official URL: https://doi.org/10.1016/j.copbio.2018.08.007

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Abstract

CRISPR-based genome editing provides a simple and scalable toolbox for a variety of therapeutic and biotechnology applications. Whilst the fundamental properties of CRISPR proved easily transferable from the native prokaryotic hosts to eukaryotic and multicellular organisms, the tight control of the CRISPR-editing activity remains a major challenge. Here we summarise recent developments of CRISPR and riboswitch technologies and recommend novel functionalised synthetic-gRNA (sgRNA) designs to achieve inducible and spatiotemporal regulation of CRISPR-based genetic editors in response to cellular or extracellular stimuli. We believe that future advances of these tools will have major implications for both basic and applied research, spanning from fundamental genetic studies and synthetic biology to genetic editing and gene therapy.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): CRISPR (Genetics), Gene editing, Riboswitches, RNA editing
Journal or Publication Title: Current Opinion in Biotechnology
Publisher: Elsevier BV
ISSN: 0958-1669
Official Date: February 2019
Dates:
DateEvent
February 2019Published
25 September 2018Available
25 September 2018Accepted
Volume: 55
Page Range: pp. 103-113
DOI: 10.1016/j.copbio.2018.08.007
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
FP7-ICT-FET-610730FP7 Information and Communication Technologieshttp://dx.doi.org/10.13039/100011273
FP7-KBBE-613745Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
642,738H2020 Marie Skłodowska-Curie Actionshttp://dx.doi.org/10.13039/100010665
BB/M017982/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
EVO-ENGINE BB/P020615/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741

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