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Functional connectivity of the precuneus in unmedicated patients with depression
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Cheng, Wei, Rolls, Edmund T., Qiu, Jiang, Yang, Deyu, Ruan, Hongtao, Wei, Dongtao, Zhao, Libo, Meng, Jie, Xie, Peng and Feng, Jianfeng (2018) Functional connectivity of the precuneus in unmedicated patients with depression. Biological psychiatry. Cognitive neuroscience and neuroimaging, 3 (12). pp. 1040-1049. doi:10.1016/j.bpsc.2018.07.008 ISSN 2451-9030.
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Official URL: https://doi.org/10.1016/j.bpsc.2018.07.008
Abstract
Background
The precuneus has connectivity with brain systems implicated in depression.
Methods.
We performed the first fully voxel - level resting state functional - connectivity neuroimaging analysis of depression of the precuneus, with 282 patients with major depressive disorder and 254 controls.
Results
In 125 unmedicated patients, voxels in the precuneus had significantly increased functional connectivity with the lateral orbito frontal cortex , a region implicated in non - reward and that is thereby implicated in depression. Functional connectivity was also increased in depression between the precuneus and dorsolateral prefrontal cortex; temporal cortex; and angular and supramarginal areas. In patients receiving medication, the functional connectivity between the lateral orbitofrontal cortex and precuneus was de creased back towards that in the controls. In the 254 controls, parcellation revealed superior anterior, superior posterior, and inferior subdivisions, with the inferior subdivision having high connectivity with the posterior cingulate cortex, parahippocampal gyrus, angular gyrus, and prefrontal cortex. It was the ventral subdivision of the precuneus that had increased connectivity in depression with the later al orbitofrontal cortex and adjoining inferior frontal gyrus.
Conclusions
The findings support the theory that the system in the lateral orbitofron tal cortex implicated in responding to not receiving expected rewards has increased effects on areas in which the self is represented, the precuneus. This may result in low self - esteem in depression. The increased connectivity of the precuneus with the pre frontal cortex short - term memory system may contribute to the rumination about low self - esteem in depression. These findings provide evidence that a target to ameliorate depression is the lateral orbitofrontal cortex.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Depression, Mental, Depressed persons, Hippocampus (Brain), Cognitive neuroscience | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Biological psychiatry. Cognitive neuroscience and neuroimaging | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Elsevier | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2451-9030 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Official Date: | 30 December 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 1040-1049 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.bpsc.2018.07.008 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 22 January 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 30 July 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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