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Drosophila immune cell migration and adhesion during embryonic development and larval immune responses

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Ratheesh, Aparna, Belyaeva, Vera and Siekhaus, Daria E (2015) Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. Current Opinion in Cell Biology, 36 . pp. 71-79. doi:10.1016/j.ceb.2015.07.003

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Official URL: http://dx.doi.org/10.1016/j.ceb.2015.07.003

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Abstract

The majority of immune cells in Drosophila melanogaster are plasmatocytes; they carry out similar functions to vertebrate macrophages, influencing development as well as protecting against infection and cancer. Plasmatocytes, sometimes referred to with the broader term of hemocytes, migrate widely during embryonic development and cycle in the larvae between sessile and circulating positions. Here we discuss the similarities of plasmatocyte developmental migration and its functions to that of vertebrate macrophages, considering the recent controversy regarding the functions of Drosophila PDGF/VEGF related ligands. We also examine recent findings on the significance of adhesion for plasmatocyte migration in the embryo, as well as proliferation, trans-differentiation, and tumor responses in the larva. We spotlight parallels throughout to vertebrate immune responses.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Cellular immunity, Macrophages, Drosophila melanogaster -- Larvae, Blood cells
Journal or Publication Title: Current Opinion in Cell Biology
Publisher: Elsevier Science BV
ISSN: 09550674
Official Date: October 2015
Dates:
DateEvent
October 2015Published
24 July 2015Available
Volume: 36
Page Range: pp. 71-79
DOI: 10.1016/j.ceb.2015.07.003
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CIG 34077/IRTIMH2020 Marie Skłodowska-Curie Actionshttp://dx.doi.org/10.13039/100010665
IIF GA-2012-32950 BB: DICJIH2020 Marie Skłodowska-Curie Actionshttp://dx.doi.org/10.13039/100010665

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