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Drosophila immune cell migration and adhesion during embryonic development and larval immune responses
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Ratheesh, Aparna, Belyaeva, Vera and Siekhaus, Daria E (2015) Drosophila immune cell migration and adhesion during embryonic development and larval immune responses. Current Opinion in Cell Biology, 36 . pp. 71-79. doi:10.1016/j.ceb.2015.07.003 ISSN 09550674.
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WRAP-drosophila-immune-cell-migration-adhesion-embryonic-development-larval-immune-responses-Ratheesh-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1111Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.ceb.2015.07.003
Abstract
The majority of immune cells in Drosophila melanogaster are plasmatocytes; they carry out similar functions to vertebrate macrophages, influencing development as well as protecting against infection and cancer. Plasmatocytes, sometimes referred to with the broader term of hemocytes, migrate widely during embryonic development and cycle in the larvae between sessile and circulating positions. Here we discuss the similarities of plasmatocyte developmental migration and its functions to that of vertebrate macrophages, considering the recent controversy regarding the functions of Drosophila PDGF/VEGF related ligands. We also examine recent findings on the significance of adhesion for plasmatocyte migration in the embryo, as well as proliferation, trans-differentiation, and tumor responses in the larva. We spotlight parallels throughout to vertebrate immune responses.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QL Zoology Q Science > QP Physiology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cellular immunity, Macrophages, Drosophila melanogaster -- Larvae, Blood cells | |||||||||
| Journal or Publication Title: | Current Opinion in Cell Biology | |||||||||
| Publisher: | Elsevier Science BV | |||||||||
| ISSN: | 09550674 | |||||||||
| Official Date: | October 2015 | |||||||||
| Dates: |
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| Volume: | 36 | |||||||||
| Page Range: | pp. 71-79 | |||||||||
| DOI: | 10.1016/j.ceb.2015.07.003 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 8 October 2018 | |||||||||
| Date of first compliant Open Access: | 9 October 2018 | |||||||||
| RIOXX Funder/Project Grant: |
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