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A bigger picture : classical cadherins and the dynamic actin cytoskeleton
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Ratheesh, Aparna and Yap, Alpha S. (2012) A bigger picture : classical cadherins and the dynamic actin cytoskeleton. Nature Reviews Molecular Cell Biology, 13 (10). pp. 673-679. doi:10.1038/nrm3431
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Official URL: http://dx.doi.org/10.1038/nrm3431
Abstract
Classical cadherin adhesion receptors influence tissue integrity in health and disease. Their biological function is intimately linked to the actin cytoskeleton. To date, research has largely focused on identifying the molecular mechanisms that physically couple cadherin to cortical actin filaments. However, the junctional cytoskeleton is dynamic. Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Nature Reviews Molecular Cell Biology | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1471-0072 | ||||
| Official Date: | 30 August 2012 | ||||
| Dates: |
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| Volume: | 13 | ||||
| Number: | 10 | ||||
| Page Range: | pp. 673-679 | ||||
| DOI: | 10.1038/nrm3431 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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