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Multilayered magnetic gelatin membrane scaffolds

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Samal, Sangram K., Goranov, Vitaly, Dash, Mamoni, Russo, Alessandro, Shelyakova, Tatiana, Graziosi, Patrizio, Lungaro, Lisa, Riminucci, Alberto, Uhlarz, Marc, Bañobre-López, Manuel, Rivas, Jose, Herrmannsdörfer, Thomas, Rajadas, Jayakumar, De Smedt, Stefaan, Braeckmans, Kevin, Kaplan, David L. and Dediu, V. Alek (2015) Multilayered magnetic gelatin membrane scaffolds. ACS Applied Materials & Interfaces, 7 (41). pp. 23098-23109. doi:10.1021/acsami.5b06813 ISSN 1944-8244.

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Official URL: http://dx.doi.org/10.1021/acsami.5b06813

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Abstract

A versatile approach for the design and fabrication of multilayer magnetic scaffolds with tunable magnetic gradients is described. Multilayer magnetic gelatin membrane scaffolds with intrinsic magnetic gradients were designed to encapsulate magnetized bioagents under an externally applied magnetic field for use in magnetic-field-assisted tissue engineering. The temperature of the individual membranes increased up to 43.7 °C under an applied oscillating magnetic field for 70 s by magnetic hyperthermia, enabling the possibility of inducing a thermal gradient inside the final 3D multilayer magnetic scaffolds. On the basis of finite element method simulations, magnetic gelatin membranes with different concentrations of magnetic nanoparticles were assembled into 3D multilayered scaffolds. A magnetic-gradient-controlled distribution of magnetically labeled stem cells was demonstrated in vitro. This magnetic biomaterial–magnetic cell strategy can be expanded to a number of different magnetic biomaterials for various tissue engineering applications.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Journal or Publication Title: ACS Applied Materials & Interfaces
Publisher: American Chemical Society
ISSN: 1944-8244
Official Date: 9 October 2015
Dates:
DateEvent
9 October 2015Published
29 September 2015Accepted
Volume: 7
Number: 41
Page Range: pp. 23098-23109
DOI: 10.1021/acsami.5b06813
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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