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Resveratrol inhibits type II phosphatidylinositol 4-kinase : a key component in pathways of phosphoinositide turn over
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Srivastava, Rupa, Ratheesh, Aparna, Gude, Rajiv K., Rao, K. V. K., Panda, Dulal and Subrahmanyam, Gosukonda (2005) Resveratrol inhibits type II phosphatidylinositol 4-kinase : a key component in pathways of phosphoinositide turn over. Biochemical Pharmacology, 70 (7). pp. 1048-1055. doi:10.1016/j.bcp.2005.07.003 ISSN 0006-2952.
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Official URL: http://dx.doi.org/10.1016/j.bcp.2005.07.003
Abstract
Resveratrol has anti-inflammatory, cardio protective and cancer chemopreventive properties. The molecular targets for resveratrol in early signaling cascades are not well understood. Resveratrol inhibits type II PtdIns 4-kinase but not PtdIns 3-kinase activity in vitro. Resveratrol directly binds to the enzyme with a Kd of 7.2 μM. Kinetic studies show that resveratrol competes with PtdIns binding. Inhibition of PtdIns 4-kinase activity by resveratrol/phenylarsine oxide reduces Jurkat cell adhesion to matrigel/fibronectin coated surfaces, suggesting a role for type II PtdIns 4-kinase in lymphocyte infiltration to the sites of inflammation.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Biochemical Pharmacology | ||||||||
Publisher: | Elsevier Inc. | ||||||||
ISSN: | 0006-2952 | ||||||||
Official Date: | 1 October 2005 | ||||||||
Dates: |
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Volume: | 70 | ||||||||
Number: | 7 | ||||||||
Page Range: | pp. 1048-1055 | ||||||||
DOI: | 10.1016/j.bcp.2005.07.003 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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